Alloxazine-Isoalloxazine-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAlloxazineCat.No.:HY-123085CASNo.:490-59-5Synonyms:Isoalloxazine分⼦式:C₁₀H₆N₄O₂分⼦量:214.18作⽤靶点:AdenosineReceptor作⽤通路:GPCR/GProtein储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Alloxazine⼀种选择性的A2b拮抗剂。Alloxazine可以完全阻断5'n-⼄羧氨腺苷(NECA)介导的环AMP积累，其IC50值为2.9μM。Alloxazine可⽤于癌症的研究。IC50&TargetIC50:2.9μM(AMP)[1]体外研究Alloxazine(0-30μM,20min)inhibitscyclicAMPproductioninPGT-βcells[1].CellViabilityAssay[1]CellLine:PGT-βcellsConcentration:0-30μMIncubationTime:20minResult:InhibitedthecyclicAMPgenerationconcentration-dependentlywithanICIC50of2.9μM.体内研究Alloxazine(1µmol/L,0-20min)suppressesNECA-inducedvasodilation[2].AnimalModel:250–320gmaleSprague-Dawleyrats[2]Dosage:1µmol/L1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAdministration:Corticalsurfacesuffusion;1µmol/LonceResult:SignificantlysuppressedvasodilationwithincreasedEC25valueof0.60µmol/L.REFERENCES[1].BrackettLE,DalyJW.FunctionalcharacterizationoftheA2badenosinereceptorinNIH3T3fibroblasts.BiochemPharmacol.1994Mar2;47(5):801-14.[2].ShinHK,etal.RoleofadenosineA(2B)receptorsinvasodilationofratpialarteryandcerebralbloodflowautoregulation.AmJPhysiolHeartCircPhysiol.2000Feb;278(2):H339-44.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792