Dovramilast-CC-11050-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDovramilastCat.No.:HY-147263CASNo.:340019-69-4Synonyms:CC-11050分⼦式:C₂₄H₂₈N₂O₆S分⼦量:472.55作⽤靶点:Phosphodiesterase(PDE)作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物Dovramilast(CC-11050)⼀种磷酸⼆酯酶4(PDE4)抑制剂，具有⼝服活性，可以减少炎症反应，改INH介导的肺部细活性IC50&PDE4Target体内研Dovramilast(oralgavage,5,25,or50mg/kg,single)significantlyimprovesantibiotic-mediatedbacterialkillingandreduceslungpatholog究PharmacokineticParametersofDovramilastinB6D2F1mice[2].Samplingtime(h)Concentration(ng/ml)CC-11050onlyCC-11050+INH11,331.6±136.97905.35±594.2321,409.47±140.851,309.39±214.085948.85±128.71,609.18±167.28820.6±265.981,271.73±24×h/ml)10,20013,900AnimalModel:B6D2F1mice[2]Dosage:5,25,or50mg/kgAdministration:oral,5,25,or50mg/kg,singleResult:ReducedPDE4expressioninmtb-infectedmouselungs.AnimalModel:B6D2F1mice[2]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEDosage:5,25,or50mg/kgAdministration:oralgavage,5,25,or50mg/kg,singleResult:Improvedantibiotic-mediatedbacterialkillingandreducedlungpathology.REFERENCES[1].InternationalNonproprietaryNamesforPharmaceuticalSubstances(INN).WHODrugInformation,Vol.36,No.2,2022.[2].SelvakumarSubbian,etal.PharmacologicInhibitionofHostPhosphodiesterase-4ImprovesIsoniazid-MediatedClearanceofMycobacteriumtuberculosis.FrontImmunol.2016Jun17;7:238.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895