Sutezolid-PNU-100480-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESutezolidCat.No.:HY-10392CASNo.:168828-58-8Synonyms:PNU-100480;U-100480;PF-02341272分⼦式:C₁₆H₂₀FN₃O₃S分⼦量:353.41作⽤靶点:Bacterial;Antibiotic作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:50mg/mL(141.48mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8296mL14.1479mL28.2957mL5mM0.5659mL2.8296mL5.6591mL10mM0.2830mL1.4148mL2.8296mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(7.07mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(7.07mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(7.07mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Sutezolid(PNU-100480)⼀种具有⼝服活性恶唑烷酮抗剂，通过抑制细蛋⽩质合成发挥作⽤。Sutezolid具有较强的抗分枝杆活性，⽤于耐药结核病的研究。IC50&TargetOxazolidinone体外研究Sutezolid(PNU-100480)exhibitsexcellentinvitroactivityagainstmultipleclinicalisolatesofMycobacteriumaviumcomplex(MIC’s=0.5-4µg/mL)[1].体内研究Sutezolid(PNU-100480)isathiomorpholinylanalogoflinezolidwithsuperiorefficacyagainstM.tuberculosisinthehollow-fiber,mouse,andwhole-bloodmodels[3].户使⽤本产品发表的科研⽂献•AntimicrobAgentsChemother.2021Jan25;AAC.01445-20.•DisModelMech.2021Oct13;dmm.049145.•JPharmBiomedAnal.2019May30;169:196-207.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].BarbachynMR,etal.Identificationofanoveloxazolidinone(U-100480)withpotentantimycobacterialactivity.JMedChem.1996;39(3):680-685.[2].NicoleSalazar-Austin,etal.Sutezolid.InKucerstheUseofAntibiotics:AClinicalReviewofAntibacterial,Antifungal,Antiparasitic,andAntiviralDrugs,SeventhEdition(pp.2559-2563).CRCPress.[3].ZhuT,etal.Populationpharmacokinetic/pharmacodynamicanalysisofthebactericidalactivitiesofsutezolid(PNU-100480)anditsmajormetaboliteagainstintracellularMycobacteriumtuberculosisinexvivowhole-bloodculturesofpatientswithpulmonarytuberculosis.AntimicrobAgentsChemother.2014;58(6):3306-3311.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications