Risdiplam-RG7916-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERisdiplamCat.No.:HY-109101CASNo.:1825352-65-5Synonyms:RG7916;RO7034067分⼦式:C₂₂H₂₃N₇O分⼦量:401.46作⽤靶点:DNA/RNASynthesis作⽤通路:CellCycle/DNADamage储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验Ethanol:<1mg/mL(insoluble)DMSO:1.7mg/mL(4.23mM;ultrasonicandwarmingandheatto60°C)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.4909mL12.4545mL24.9091mL5mM---------10mM---------请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Risdiplam(RG7916)⼀种运动神经元存活因SMN2的前体mRNA剪接修饰剂，可增加SMN蛋⽩⽔平1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1]。IC50&TargetSMN2体外研究RisdiplammodulatesSMN2pre-mRNAsplicingtowardstheproductionoffull-lengthSMN2mRNAandincreasesSMNproteinlevels.RisdiplamisamodifierofSMN2splicing,leadingtoanincreaseinSMN2fulllengthtranscriptandthusfunctionalSMNprotein.Spinalmuscularatrophy(SMA)typeIremainsthemostcommongeneticdiseaseresultingindeathininfancy.Characterizedbyprogressivemotorandrespiratorymuscleweakness,thisautosomalrecessiveneuromusculardisorderiscausedbylowlevelsofthesurvivalmotorneuronprotein(SMN)duetoinactivatingbi-allelicdeletionsandotherdisablingmutationsinthesurvivalmotorneuron1(SMN1)gene[1].户使⽤本产品发表的科研⽂献•NucleicAcidsRes.2021Sep7;49(15):8462-8470.•CellMolLifeSci.2022Jul22;79(8):441.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].PoirierA,etal.RisdiplamdistributesandincreasesSMNproteininboththecentralnervoussystemandperipheralorgans.PharmacolResPerspect.2018Nov29;6(6):e00447.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820