GW806742X-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGW806742XhydrochlorideCat.No.:HY-112292A分⼦式:C₂₅H₂₃ClF₃N₇O₄S分⼦量:610.01作⽤靶点:MixedLineageKinase;VEGFR作⽤通路:MAPK/ERKPathway;ProteinTyrosineKinase/RTK储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:100mg/mL(163.93mM;Needultrasonic)H2O:<0.1mg/mL(ultrasonic)(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6393mL8.1966mL16.3932mL5mM0.3279mL1.6393mL3.2786mL10mM0.1639mL0.8197mL1.6393mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(4.10mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(4.10mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性GW806742Xhydrochloride⼀种ATP模拟物，⼀种有效的MLKL抑制剂，结合MLKL假激酶结构域，Kd值为9.3μM。GW806742Xhydrochloride具有抗VEGFR2的活性(IC50=2nM)。GW806742Xhydrochloride延缓MLKL膜移位并抑制坏死。IC50&TargetMLKLVEGFR29.3μM(Kd)2nM(IC50)体外研究GW806742X(0.1-10000nM)inhibitsnecroptoticdeathofwild-typemousedermalfibroblasts(MDFs)stimulatedwithTSQ(1ng/mLTNF,500nMcompoundA(Smacmimetic),10μMQ-VD-OPh)inadose-dependentmanner[1].GW806742XshowsinhibitionofVEGFinducedproliferationofHUVECswithanIC50of5nM[2].户使⽤本产品发表的科研⽂献•Autophagy.2021Jul20;1-19.•MicrobiolSpectr.2022Jun16;e0104522.•ActaPharmacolSin.2021Aug10.•ActaHistochem.2022May;124(4):151875.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HildebrandJM,etal.ActivationofthepseudokinaseMLKLunleashesthefour-helixbundledomaintoinducemembranelocalizationandnecroptoticcelldeath.ProcNatlAcadSciUSA.2014;111(42):15072-15077.[2].SammondDM,etal.DiscoveryofanovelandpotentseriesofdianilinopyrimidineureaandureaisostereinhibitorsofVEGFR2tyrosinekinase.BioorgMedChemLett.2005;15(15):3519-3523.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forrese