Danicopan-ACH-4471-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDanicopanCat.No.:HY-117930CASNo.:1903768-17-1Synonyms:ACH-4471分⼦式:C₂₆H₂₃BrFN₇O₃分⼦量:580.41作⽤靶点:ComplementSystem作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(430.73mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7229mL8.6146mL17.2292mL5mM0.3446mL1.7229mL3.4458mL10mM0.1723mL0.8615mL1.7229mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.08mg/mL(3.58mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.58mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Danicopan(ACH-4471)⼀种选择性的⼝服活性factorD抑制剂，对factorD具有⾼结合亲和⼒，其Kd值为0.54nM。Danicopan(ACH-4471)可抑制补体(APC)活性的替代途径，具有阻断阵发性夜间⾎红蛋⽩尿(PNH)和⾮典型溶⾎性尿毒症综合征(aHUS)的补体替代途径的潜⼒。IC50&TargetKd:0.54nM(FactorD)[1]体外研究Danicopan(ACH-4471)inhibitstheproteolyticactivityofpurifiedFactorDagainstitsnaturalsubstrateFactorBincomplexwithC3b,blockingproductionofBbfragmentinadose-dependentmannerwithanIC50valueof0.015μM[1].Danicopan(ACH-4471)potentlyinhibitshemolysiswithIC50valuesrangingfrom0.0040μMto0.027μM(IC90valuesfrom0.015μMto0.11μM)[1].户使⽤本产品发表的科研⽂献•FrontImmunol.2021Jun10;12:690821.•Cancers(Basel).2022,14(2),305.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].YuanX,etal.Small-moleculefactorDinhibitorsselectivelyblockthealternativepathwayofcomplementinparoxysmalnocturnalhemoglobinuriaandatypicalhemolyticuremicsyndrome.Haematologica.2017Mar;102(3):466-475.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.T