Pinacidil-P-1134-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPinacidilCat.No.:HY-14290CASNo.:60560-33-0Synonyms:P-1134分⼦式:C₁₃H₁₉N₅分⼦量:245.32作⽤靶点:PotassiumChannel作⽤通路:MembraneTransporter/IonChannel储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(407.63mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.0763mL20.3815mL40.7631mL5mM0.8153mL4.0763mL8.1526mL10mM0.4076mL2.0382mL4.0763mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(10.19mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(10.19mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(10.19mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Pinacidil⼀种有效的钾通道(potassiumchannel)激活剂。Pinacidil⼀种抗⾼⾎压药，通过打开K+-通道使⾎管平滑肌超极化。Pinacidil显改再灌注功能和⼼脏应性。Pinacidil具有直接的⼼脏保护作⽤[1]。IC50&Targetpotassiumchannel[1]户使⽤本产品发表的科研⽂献•DevCell.2022May11;S1534-5807(22)00287-8.•BoneRes.2022Mar8;10(1):25.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GroverGJ,etal.Anti-ischemiceffectsofthepotassiumchannelactivatorspinacidilandcromakalimandthereversaloftheseeffectswiththepotassiumchannelblockerglyburide.JPharmacolExpTher.1989;251(1):98-104.[2].HamiltonTC,etal.Cromakalim,nicorandilandpinacidil:noveldrugswhichopenpotassiumchannelsinsmoothmuscle.GenPharmacol.1989;20(1):1-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-