catosal科特壮犬猫疾病支持治疗药物演示文稿

catosal科特壮犬猫疾病支持治疗药物演(Yan)示文稿第一页，共三十一页。支持治(Zhi)疗支持治疗是指与特异性疗法配合的附加治疗,它可以缩短犬猫疾病的康复时间！第二页，共三十一页。支持(Chi)治疗支持治疗是指与特异性疗法配合的附加治疗,它可以缩短犬猫疾病的康复时间！第三页，共三十一页。支持治疗对犬猫的重(Zhong)要性

一般来说，疾病会降低犬猫新陈代谢机能，而新陈代谢机能降低又会延缓犬猫的康复。临床上特异性治疗不会恢复患病犬猫的新陈代谢机能。所以促进新陈代谢的支持治疗性药物会明显促进患病宠物的康复。第四页，共三十一页。患病犬猫需要额外的能量来帮助疾病康(Kang)复总结简而言之:患病动物需要更多的能量:正常的身体功能需要从疾病中快速康复

第五页，共三十一页。支持治(Zhi)疗形式平衡营养充足休息注意管理增加多种维生素和矿物质保护肝脏等第六页，共三十一页。ATP+H2O ADP+HPO4ENERGY脂类和糖类最终利(Li)用的形式(ATP)ATP变成ADP并释放细胞利用的能量(如:提供给肌肉细胞)能量的利用方式第七页，共三十一页。能(Neng)量–重要的因素整个新陈代谢过程关键因素是磷元素的代谢磷元素在AMP-ADP-ATP循环后,有部分会流失掉理论上,磷元素加入到ADP分子中是提供能量储备的最好方式第八页，共三十一页。能量–理想的支持治(Zhi)疗磷会流失,需要不断补充提供含能量储备的磷能帮助细胞更好的工作!随着能量需求的增加,富含能量的磷混合物可以满足新陈代谢的需求第九页，共三十一页。第十页，共三十一页。CATOSAL就是答(Da)案每ml含量:布他磷 100.00mg VitB12 0.05mg Methylparaben 1.00mgPhosphoruscontent:17.3mg/ml提供磷元素提供维生素其他作用成分磷含量:17.3mg/mlCatosal–疾病支持治疗的关键第十一页，共三十一页。科特壮(Zhuang)的成分布他磷

有机磷酸无味的白色晶体VB12ButaphosphaneVitaminB12+ThePowerofPink第十二页，共三十一页。科特壮的(De)成分布他磷无味的白色晶体作用机理通过促进ADP-ATP循环，促进机体能量代谢。促进机体的合成代谢过程。激活犬猫机体非特异性免疫反应恢复疲劳肌肉功能。第十三页，共三十一页。缓解应激/降低(Di)激素水平DeGrootJ.,vanDerWerfJ.,vanReenenC.,SchuurmanT.,SchmidtB.(2003):Theeffectofbutafosfan(componentofCatosal)onpsychosocialstressinpigs.J.Vet.Pharmacol.Therap.26(Suppl.1),222-223.VanderStaayJ.,DeGrootJ.,SchmidtB.,SchuurmanT.(2006):EffectsofCatosalonthephysiologicalandbehavioralresponsetosocialstressinpiglets.Proceedingsofthe19thIPVSCongress,Copenhagen,Denmark,Volume2.SimonF(1990):Studyonstressreducingeffectofbutafosfaninsheep.InstitutfürPharmakologieundToxikologie,VeterinärmedizinischeUniversität,Budapest,Hungary.BayerID12765.HänselA.,FuhrmannH.,SallmannH.-P,KleeW.(1992):InfusionvonPropionateandButyratalsBelastungstestzurÜberprüfungmöglicherButafosfanwirkungenaufdenEnergiestoffwechseldesRindes.Berl.Münch.Tierärztl.Wschr.105,361-366.HasiSu-rong,DUXiao-yan,ZHUBei-lei,JIANGJin-shu(2004a):StudiesonEffectsofCompoundButaphosphanSolutiononEnduranceCapabilityandEnergyMetabolisminMice.ActaVeterinariaEtZootechnicaSinica,35(03),290-294.第十四页，共三十一页。降(Jiang)低冷热刺激StressReduction/controlofcortisolincrease.HasiSu-rongetal.(2004a)*:p<0.05,**p<:0.001comparedtocontrolgroup***:p<0.05comparedtohighdosebutaphosphan******%Highdosebutaphosphan(n=15):250mg/kgbutaphosphanonceadayfor7daysorally.Lowdosebutaphosphan(n=15)125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=15):10ml/kgphysiologicsalineonceadayfor7daysoral.Onehouraftertreatmentonthelastday,eachmousewasplacedIna300mlwide-mouthedflaskwhichwassealedwithadoublelayerofgauze.Inordertoevaluatethecoldtolerance,thiswasplacedinametaboliccageat5±0.5ºCwithacyclicpump.But,fortheevaluationofheattolerancethetemperaturewas45±0.5ºC.Inthecoldtolerancestudy,after10hoursthenumberofmicestillalivewasrecorded.Intheheattolerancestudy,after50minutes,thenumberofmicestillalivewasrecorded第十五页，共三十一页。.布他磷作用于组织(Zhi)缺氧HasiSu-rongetal.(2004a)*p<:0.05,**p<:0.001comparedtocontrolgroup***存活时间(分钟)Highdosebutaphosphan(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Lowdosebutaphosphan(n=12)125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalineonceadayfor7daysoral.Onehouraftertreatmentonthelastday,eachmousewasplacedIna300mlwide-mouthedflaskwhichwassealedwithtransparentgladwrapThatdidnotadmitairandtimingwascommenced.Withtheterminationofbreathingastheendpoint,thetimeforeachmousetoexpirefromlackofoxygenwasnoted,soastodeterminetheeffectofbutaphosphanonthetoleranceofmicehypoxia.第十六页，共三十一页。刺激能量产(Chan)生参考资料:HasiSu-rong,DUXiao-yan,ZHUBei-lei,JIANGJin-shu(2004a):StudiesonEffectsofCompoundButaphosphanSolutiononEnduranceCapabilityandEnergyMetabolisminMice.ActaVeterinariaEtZootechnicaSinica,35(03),290-294.HASISu-rong,JIANGJin-shu,DUXiao-yan,ZHUBei-lei(2005a):Anti-coldstresseffectsandmechanismsofcompoundbutaphosphansolution.ProgressinVeterinaryMedicine,26,(03),59-62.HASISu-rong,JIANGJin-shu,ZHUBei-lei,DUXiao-yan(2005b):StudiesonAnti-HeatStressEffectsandMechanismsofCompoundButafosfanSolution.ActaVeterinariaEtZootechnicaSinica,36(12),1334-1338.第十七页，共三十一页。布他磷刺激肝糖元产生Contentoflivergycogen(mg/g)*****=p<0.05,***=p<0.001ComparedtocontrolgroupHasiSu-rongetal.(2004a)Experiment1(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Experiment2(n=12):125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalinesolution.Onehourafterlasttreatmentonthelastday,miceweresacrificedandliverglycogencontentwasdeterminedviaspectrometer第十八页，共三十一页。布他磷刺激肌糖元产生Contentofmuscleglycogen(mg/g)*******=p<0.01,***=p<0.001ComparedtocontrolgroupHasiSu-rongetal.(2004a)Experiment1(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Experiment2(n=12):125mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalinesolution.Onehourafterlasttreatmentonthelastday,miceweresacrificedandmuscleglycogencontentwasdeterminedviaspectrometer第十九页，共三十一页。提高肌肉中的Tri-phosphate(ATP)含量ContentofmuscleATP(mg/g)******=p<0.001ComparedtocontrolgroupHasiSu-rongetal.(2004a)Butaphosphantreatmentgroup(n=12):250mg/kgbutaphosphanonceadayfor7daysorally.Controlgroup(n=12):10ml/kgphysiologicsalinesolution.Onehourafterlasttreatmentonthelastday,miceweresacrificedandmuscleATPcontentwasdeterminedviaHPLC.第二十页，共三十一页。提(Ti)高肝脏功能StudiesFürllM.,WitteckTh.,GengenbachS.,SchmidtB.(2006):Effectsofpre-operativeapplicationofbutaphosphanandcyanocobalamineonreconvalescenceclinico-chemicalparameters,antioxidavivemetabolismandpostoperativeabomosalemptyingincowswithabomosaldislocation.Tierärztl.Prax.34(G):351-356.HASISu-rong,JIANGJin-shu,DUXiao-yan,ZHUBei-lei(2005a):Anti-coldstresseffectsandmechanismsofcompoundbutaphosphansolution.ProgressinVeterinaryMedicine,26,(03),59-62.HASISu-rong,JIANGJin-shu,ZHUBei-lei,DUXiao-yan(2005b):StudiesonAnti-heatStressEffectsandMechanismsofCompoundButafosfanSolution.ActaVeterinariaEtZootechnicaSinica,36(12),1334-1338.SommerH.,MarxD.,undStarkerG.(1971):StudiestoreducereproductivedisordersincattlebyusingCatosal®asmetaphylaxis.Dtsch.Tierärtzl.Wschr.78,593–616..FlasshoffF.-H.(1974):Clinicalandchemicalbloodseruminvestigationsincattleandtreatmentstudieswithornithine-aspartate-productHMV20andwithCatosalforthereductionoffertilityandhealthdisorders.DoctorateThesis,TierärztlicheHochschuleHannover,Germany.MarbachW(1980):AlkalischePhosphatase(AP)undAspartataminotransferase(AST)desBlutplasmasalsParameterderKonditionvonRennpferdenunddieWirkungvonCoforta/CatosalaufdieseEnzyme.Vet.Med.Nahchr.,12.第二十一页，共三十一页。CATOSAL:营养(Yang)肝脏ASAT(U/l)50100150200250300350Catosal对照组谷草转氨酶(ASAT)是一种线粒体内的酶，当肝脏或肌肉损伤或肝脏代谢负担过重是会释放到血液中。科特壮能促进糖异生的过程，这样减轻肝脏的负担。0d1d2d3dpostOP科特壮-药理作用第二十二页，共三十一页。

游离脂肪酸(µmol/l)20060010001400180022000d1d2d3dCATOSAL:营(Ying)养肝脏血液中的游离脂肪酸含量是脂肪代谢的指标，脂肪代谢不好时其含量高用科特壮治疗后游离脂肪酸含量比未治疗明显降低Catosal对照组Catosal–

药理作用第二十三页，共三十一页。科(Ke)特壮的成分VB12水溶性,提供钴元素需要不断摄入作用方式调节蛋白质、脂类和碳水化合物的新陈代谢提供钴元素，帮助红细胞合成。促进蛋氨酸合成，而蛋氨酸是机体蛋白质重要的合成原料。促进身体生长,提高食物利用率。黑色晶体,吸水性第二十四页，共三十一页。科特壮-药(Yao)理作用CATOSAL:抗氧化作用布他磷是一种α-氨基磷酸,可以保护犬猫机体免受氧化损伤。CATOSAL:促进生长发育布他磷能够影响宠物的中间代谢（GIESECKE1985），主要表现为促进能量代谢、提高蛋白质合成（KAEMMERER1984,KIETZMANN1986）和促进生长发育。实验证明，给予科特壮、维生素以及硒元素可使动物生长速度提高38%（El-Sherifetal.,19