ABT-510-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEABT-510Cat.No.:HY-13545CASNo.:251579-55-2分⼦式:C₄₆H₈₃N₁₃O₁₁分⼦量:994.23SequenceShortening:Ac-{Gly-Me}-GVIT-{Nva}-IRP作⽤靶点:Apoptosis作⽤通路:Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性ABT-510⼀种抗⾎管⽣成TSP肽(thrombospondin-1类似物)，能诱导肿瘤细胞凋亡并抑制上⽪性巢癌正位、同种异体模型中的巢肿瘤⽣长。ABT-510还可减少⼩⿏炎症性肠病模型的⾎管⽣成和炎症反应。ABT-510可⽤于癌症(尤其上⽪性巢癌)以及炎症性肠病(IBD)的研究。体外研究ABT-510(1,5,10,20,50nM;24h)inducesapoptosisinID8cellsand(50nM;24h)increasestheincidenceofapoptosisinthehumanepithelialcancercelllinesSKOV3,OVCAR3,andCAOV3[1].ApoptosisAnalysis[1]CellLine:ID8,SKOV3,OVCAR3,andCAOV3cellsConcentration:1,5,10,20,50nMIncubationTime:24hResult:InducedID8cellsapoptosisandincreasedinapoptosisinthehumanEOCcelllinesSKOV3,OVCAR3,andCAOV3.体内研究ABT-510(100mg/kg;i.p.;singledailyfor90days)leadstoasignificantreductionintumorsize,ascitesfluidvolume,andsecondarylesiondisseminationinmice[1].ABT-510(100mg/kg;I.p.;singledailyfor90days)inducescellsapoptosisinvivo[1].ABT-510(60mg/kg;osmoticminipumpsfors.c.;singledailyfor7days)decreasesangiogenesisandinflammationinamurinemodelofinflammatoryboweldisease[2].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAnimalModel:TSP-1-Nullmice(C57BL/6background;orthotopic,syngeneicmodelofepithelialovariancancer)[1].Dosage:100mg/kgAdministration:Intraperitonealinjection;singledailyfor90daysResult:Reducedovariantumorgrowthinwild-typeandTSP-1-NullMice.Significantlyreducedthevolumeofascitesandcompletelyabolishedtheformationofperitoneallesions.Reversedovariantumorhypervascularizationandincreasedtheproportionofmaturebloodvessels.AnimalModel:TSP-1-Nullmice(C57BL/6background;6-week-old;DSS-inducedinflammatoryboweldiseasemurinemodel)[2].Dosage:60mg/kgAdministration:Subcutaneouslyimplantedosmoticminipumps(0.5µL/h);singledailyfor7daysResult:SignificantlydelayedDSS-inducedbleedingandimprovedtheoverallseverityofdisease.SignificantlydiminishedinflammationgradingandangiogenesisREFERENCES[1].GreenawayJ,etal.ABT-510inducestumorcellapoptosisandinhibitsovariantumorgrowthinanorthotopic,syngeneicmodelofepithelialovariancancer.MolCancerTher.2009Jan;8(1):64-74.[2].PunekarS,etal.Thrombospondin1anditsmimeticpeptideABT-510decreaseangiogenesisandinflammationinamurinemodelofinflammatoryboweldisease.Pathobiology.2008;75(1):9-21.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplicat