24小时周期变动的生理课件

Ch14:Biologicalrhythms,sleep,anddreaming.2010.05.21.Introduction.Biologicalrhythms.Circadianrhythms.Suprachiasmicnucleus.Sleepingandwaking.Sleepstages.Sleeppatternschangeacrosslifespan.Neuralmechanismsunderlyingsleeping.Biologicalrhythms.

Circadianrhythms.24小時週期變動的生理、行為變化。夜行性動物日入而做，日出而息。Biologicalrhythms.

Zitgeberstimegiver時間線索free-runningentrainmentBiologicalrhythms.Richter(1967):clockmustbeinthebrain.Suprachiasmicnucleus.上視交叉神經核Lesion.Slice.Transplants.Biologicalrhythms.破壞SCNBiologicalrhythms.Biologicalrhythms.taugeneLessthan20hours.Transplantation.19.5hourratherthan24.05hours.Biologicalrhythms.melanopsin.Biologicalrhythms.melanopsinrhodopsinBiologicalrhythms.melanopsinBiologicalrhythms.HomozygousClock/Clockmouse.Normallightcue(LD)Dimlight(DD)Biologicalrhythms.Rhythms.Circadian:24hrs.Ultradian:<24hors.Circannualclock:1year.Infradian:>1daySleepingandwaking.EEG/EMG/EOG.Sleepingandwaking.Sleepingandwaking.

Sleepingandwaking.

Sleepingandwaking.Dolphins.Birds.Sleepingandwaking.Infants:16weeks.Sleepingandwaking.Sleepingandwaking.Sleepingandwaking.剝奪睡眠(sleepdeprivation)11days(264hrs)Sleepingandwaking.Sleepless:Meddis(1977)70-year-old.Day1-2:Day3-5:67min.

Sleepingandwaking.Sleepingandwaking.Insomnia失眠Sleepapnea.Hypersomnia.Narcolepsy.CatalplexySleepattackSleepingandwaking.缺少neurpeptidehypocretinSleepingandwaking.Sleepapnea.睡眠呼吸中止症Sleepingandwaking.Suddeninfantdeathsyndrome(SIDS)Conclusion.Biologicalrhythms.Circadianrhythms.Hypothalamus.Sleepingandwaking.Sle