Parbendazole-Standard-SKF-29044-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEParbendazole(Standard)Cat.No.:HY-115364RCASNo.:14255-87-9Synonyms:SKF29044(Standard)分子式:C₁₃H₁₇N₃O₂分子量:247.29作用靶点:Microtubule/Tubulin;Parasite作用通路:CellCycle/DNADamage;Cytoskeleton;Anti-infection储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:4mg/mL(16.18mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.0438mL20.2192mL40.4384mL5mM0.8088mL4.0438mL8.0877mL10mM0.4044mL2.0219mL4.0438mLBIOLOGICALACTIVITY生物活性Parbendazole(Standard)是Parbendazole的分析标准品。本产品用于研究及分析应用。Parbendazole是一种有效的microtubule重组抑制剂，能够破坏微管蛋白，EC50值为530nM，具有广谱的驱虫作用。IC50&TargetEC50:530 nM(tubulin)[1]REFERENCESLoYC,etal.ComputationalCellCycleProfilingofCancerCellsforPrioritizingFDA-ApprovedDrugswithRepurposingPotential.SciRep.2017Sep12;7(1):11261.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEHavercroftJC,etal.Bindingofparbendazoletotubulinanditsinfluenceonmicrotubulesintissue-culturecellsasrevealedbyimmunofluorescencemicroscopy.JCellSci.1981Jun;49:195-204.FosterKE,etal.Amutantbeta-tubulinconfersresistancetotheactionofbenzimidazole-carbamatemicrotubuleinhibitorsbothinvivoandinvitro.EurJBiochem.1987Mar16;163(3):449-55.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: