Rapamycin-GMP-Like-Sirolimus-GMP-Like-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERapamycin(GMPLike)Cat.No.:HY-10219GLCASNo.:53123-88-9Synonyms:Sirolimus(GMPLike);AY-22989(GMPLike)分⼦式:C₅₁H₇₉NO₁₃分⼦量:914.17作⽤靶点:mTOR作⽤通路:PI3K/Akt/mTOR储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Rapamycin(Sirolimus)GMPLikeGMPLike级别的Rapamycin(HY-10219)。GMPLike级别的⼩分⼦可⽤做细胞疗法中的辅助试剂。Rapamycin⼀种有效且特异性的mTOR抑制剂。体外研究RapamycinGMPLike(1nM;2-3weeks)inducesinvitrodifferentiationofhumanembryonicstemcell(hESCs)intomineralizedosteoblasts[1].RapamycinGMPLike(1nM;2-3weeks)enhancestheosteoblasticdifferentiationofhumanembryoidbodies(hEBs)[1].RapamycinGMPLike(20nM;4h)serum-dependentlypromotesvascularsmoothmusclecells(VSMCs)differentiation[2].RapamycinGMPLikeinducesosteoblasticdifferentiationinratosteoblast-likeosteosarcomacells[3].REFERENCES[1].LeeKW,etal.RapamycinpromotestheosteoblasticdifferentiationofhumanembryonicstemcellsbyblockingthemTORpathwayandstimulatingtheBMP/Smadpathway.StemCellsDev.2010Apr;19(4):557-68.[ContentBrief][2].MartinKA,etal.Rapamycinpromotesvascularsmoothmusclecelldifferentiationthroughinsulinreceptorsubstrate-1/phosphatidylinositol3-kinase/Akt2feedbacksignaling.JBiolChem.2007Dec7;282(49):36112-20.[ContentBrief][3].OgawaT,etal.Osteoblasticdifferentiationisenhancedbyrapamycininratosteoblast-likeosteosarcoma(ROS17/2.8)cells.BiochemBiophysResCommun.1998Aug10;249(1):226-30.[ContentBrief]McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5