Saquinavir-mesylate-Standard-Ro-31-8959-003-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemESaquinavirmesylate(Standard)Cat.No.:HY-17003RCASNo.:149845-06-7Synonyms:Ro31-8959/003(Standard)分子式:C₃₉H₅₄N₆O₈S分子量:766.95作用靶点:HIV;HIVProtease;Autophagy作用通路:Anti-infection;MetabolicEnzyme/Protease;Autophagy储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:16.67mg/mL(21.74mM;Needultrasonic)SolventMass1mg5mg10mgConcentration制备储备液1mM1.3039mL6.5193mL13.0387mL5mM0.2608mL1.3039mL2.6077mL10mM0.1304mL0.6519mL1.3039mLBIOLOGICALACTIVITY生物活性Saquinavir(mesylate)(Standard)是Saquinavir(mesylate)的分析标准品。本产品用于研究及分析应用。SaquinavirMesylate(Ro31-8959/003)是HIV蛋白酶抑制剂，用于逆转录病毒研究。REFERENCESKaldoretal(1995)Isophthalicacidderivatives:aminoacidsurrogatesfortheinhibitionofHIV-1protease.Bioorg.Med.Chem.Lett.5721.YerinoGA,HalabeEK,ZiniE,FelederEC.Bioequivalencestudyoftwooraltabletformulationscontainingsaquinavirmesylateboostedwithritonavirinhealthymalesubjects.Arzneimittelforschung.2011;61(8):481-7.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEBranhamML,MoyoT,GovenderT.Preparationandsolid-statecharacterizationofballmilledsaquinavirmesylateforsolubilityenhancement.EurJPharmBiopharm.2012Jan;80(1):194-202.BrouwersJ,VermeireK,GrammenC,ScholsD,AugustijnsP.Earlyidentificationofavailabilityissuesforpoorlywater-solublemicrobicidecandidatesinbiorelevantmedia:acasestudywithsaquinavir.AntiviralRes.2011Aug;91(2):217-23.KnechtenH,LutzT,PulikP,MartinT,TappeA,JaegerH.SafetyandEfficacyinHIV-1-InfectedPatientsTreatedwithRitonavir-BoostedSaquinavirMesylate.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;