LDH-IN-5-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemELDH-IN-5Cat.No.:HY-179027CASNo.:2768522-31-0分子式:C₃₆H₅₁BrO₆分子量:659.69作用靶点:LactateDehydrogenase;Apoptosis;ReactiveOxygenSpecies(ROS);SOD作用通路:MetabolicEnzyme/Protease;Apoptosis;Immunology/Inflammation;NF-κB储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性LDH-IN-5是一种具有神经保护活性的乳酸脱氢酶(LDH)抑制剂。LDH-IN-5能够抑制细胞凋亡(apoptosis)，减少活性氧(ROS)、丙二醛(MDA)的产生，并提高超氧化物歧化酶(SOD)的活性。LDH-IN-5可用于神经系统疾病的研究，如缺血性脑卒中[1]。体外研究LDH-IN-5(Compounds6b)(12.5-50μM,6h)significantlyincreasescellviabilityandreducesLDHreleaseinmousehippocampalneuronHT22cells[1].体内研究LDH-IN-5(Compounds6b)(125-500μg/mL,18h)significantlyreducestheincidenceofcerebralthrombosisin2dpfalbinozebrafishmodelsinducedbyPonatinib(HY-12047)[1].AnimalModel:2dpfalbinozebrafishmodelsinducedbyPonatinib(HY-12047)[1]Dosage:125-500μg/mLAdministration:18hResult:Showedthethrombosisincidencedecreasesby97%inthe125μg/mLdosegroupand77%inthe500μg/mLdosegroup.Showednozebrafishdeathorobvioustoxicityat500μg/mL.REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEWangX,etal.Design,synthesisandevaluationofNBP/borneolhybridsasneuroprotectiveagentsforthetreatmentofischemicstroke.BioorgChem.2025Oct;165:109056.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax