L-Phenylalanine-d-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEL-Phenylalanine-dCat.No.:HY-178251SCASNo.:55836-70-9分子式:C₉H₁₀DNO₂分子量:166.2作用靶点:Isotope-LabeledCompounds;CalciumChannel;iGluR;EndogenousMetabolite作用通路:Others;MembraneTransporter/IonChannel;NeuronalSignaling;MetabolicEnzyme/Protease储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性L-Phenylalanine-d是氘代标记的L-Phenylalanine(HY-N0215)。L-Phenylalanine((S)-2-Amino-3-phenylpropionicacid)是分离自大肠杆菌的必需氨基酸。L-Phenylalanine是一种电压依赖性α2δ亚基Ca2+通道拮抗剂，Ki为980nM。L-Phenylalanine是NMDARs(KB573μM)和非NMDARs的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine广泛用于食品香料和药品的生产中。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCESGlushakovAV,etal.Long-termchangesinglutamatergicsynaptictransmissioninphenylketonuria.Brain.2005Feb;128(Pt2):300-7.GlushakovAV,etal.L-phenylalanineselectivelydepressescurrentsatglutamatergicexcitatorysynapses.JNeurosciRes.2003Apr1;72(1):116-24.GlushakovAV,etal.SpecificinhibitionofN-methyl-D-aspartatereceptorfunctioninrathippocampalneuronsbyL-phenylalanineatconcentrationsobservedduringphenylketonuria.MolPsychiatry.2002;7(4):359-67.MortellKH,etal.Structure-activityrelationshipsofalpha-aminoacidligandsforthealpha2deltasubunitofvoltage-gatedcalciumchannels.BioorgMedChemLett.2006Mar1;16(5):1138-41.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0