BMS-986020-sodium-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEBMS-986020sodium(Standard)Cat.No.:HY-100619ARCASNo.:1380650-53-2分子式:C₂₉H₂₅N₂NaO₅分子量:504.51作用靶点:LPLReceptor;ReferenceStandards作用通路:GPCR/GProtein;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 BMS-986020(sodium)(Standard)是BMS-986020(sodium)(HY-100619A)的分析标准品。本产品用于研究及分析应用。BMS-986020(AM152)sodium是高亲和力溶血磷脂酸受体1(LPA1)拮抗剂。BMS-986020sodium抑制胆汁酸和磷脂转运蛋白，抑制BSEP，MRP4和MDR3，IC50值分别为4.8μM，6.2μM和7.5μM。BMS-9860IC50&Target IC50:4.8μM(BSEP);6.2μM(MRP4);7.5μM(MDR3)[2]REFERENCESKiharaY,etal.Lysophospholipidreceptorsindrugdiscovery.ExpCellRes.2015May1;333(2):171-7.GlennRosen,etal.LPA1antagonistsBMS-986020andBMS-986234foridiopathicpulmonaryfibrosis:Preclinicalevaluationofhepatobiliaryhomeostasis.EuropeanRespiratoryJournal.PalmerSM,etal.Randomized,Double-Blind,Placebo-Controlled,Phase2TrialofBMS-986020,aLysophosphatidicAcidReceptorAntagonistfortheTreatmentofIdiopathicPulmonaryFibrosis.Chest.2018Nov;154(5):1061-1069.AdriennePena,etal.Autoradiographicevaluationof[18F]BMT-083133,alysophosphatidicacidreceptor1(LPA1)radioligand.Thejornalofnuclearmedicine.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:02