1-Monopalmitin-d31-Glyceryl-palmitate-d-sub-31-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE1-Monopalmitin-d31Cat.No.:HY-W009141SSynonyms:Glycerylpalmitate-d31分⼦式:C₁₉H₇D₃₁O₄分⼦量:361.69作⽤靶点:Isotope-LabeledCompounds;P-glycoprotein;PI3K;Apoptosis;Caspase;IAP;Akt作⽤通路:Others;MembraneTransporter/IonChannel;PI3K/Akt/mTOR;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性1-Monopalmitin-d31(Glycerylpalmitate-d31)氘代标记的1-Monopalmitin(HY-W009141)。1-Monopalmitin(Glycerylpalmitate)PI3K/Akt通路的激活剂及P-糖蛋⽩(P-gp)抑制剂。1-Monopalmitin可诱导癌细胞G2/M期阻滞和caspase依赖的凋亡，同时抑制IAPs蛋⽩表达。1-Monopalmitin可通过抑制肠道Caco-2细胞的P-gp活性增加药物积累。1-Monopalmitin具有诱导保护性⾃噬，诱导肺癌细胞凋亡(IC50=50-58μg/mL)，对正常细胞毒性较低。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].NiuL,etal.1-MonopalmitinpromoteslungcancercellsapoptosisthroughPI3K/Aktpathwayinvitro.EnvironmentalToxicology,2023,38(11):2621-2631.[2].TomokoKonishi,etal.AbittermelonextractinhibitstheP-glycoproteinactivityinintestinalCaco-2cells:monoglycerideasanactivecompound.Biofactors.2004;22(1-4):71-4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax