2-5A-TEA-2-5-ApApA-TEA-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE2-5ATEACat.No.:HY-173189BCASNo.:72351-33-8Synonyms:2′,5′-ApApATEA;2′,5′-trioligoadenylateTEA;5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine

TEA分⼦式:C₃₀H₄₀N₁₅O₂₅P₅·xC₆H₁₅N作⽤靶点:RSV;DNA/RNASynthesis作⽤通路:Anti-infection;CellCycle/DNADamage储存⽅式:Solution,-20°C,2years*Insolvent:-80°C,6months;-20°C,1month(2years)BIOLOGICALACTIVITY⽣物活性2-5A(2′,5′-ApApA;2′,5′-trioligoadenylate;5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine)TEA⼀种5'-三磷酸化(2',5')寡腺苷酸。2-5ATEA⼀种免疫递质，能够增强RNaseL免疫⼒。2-5ATEA通过与RNaseL结合并激活其内切核糖核酸酶活性来降解病毒mRNA并抑制蛋⽩质合成。2-5ATEA可⽤于呼吸道合胞病毒(RSV)和癌症研究[1]。REFERENCES[1].KalinichenkoEN,etal.3'-Fluoro-3'-deoxyanalogsof2-5A5'-monophosphate:bindingto2-5A-dependentendoribonucleaseandsusceptibilityto(2'-5')phosphodiesterasedegradation.BiochemBiophysResCommun.1990Feb28;167(1):20-6.[2].BarnardDL,etal.2-5A-DNAconjugateinhibitionofrespiratorysyncytialvirusreplication:effectsofoligonucleotidestructuremodificationsandRNAtargetsiteselection.AntiviralRes.1999Apr;41(3):119-34.[3].WangS,LiL.2-5AisanimmunotransmitterthatfuelsRNaseLimmunity.Immunity.2025Apr8;58(4):770-772.[4].HuaiW,etal.OAScross-activatesRNaseLintercellularlythroughcell-to-celltransferof2-5Atospreadinnateimmunity.Immunity.2025Apr8;58(4):797-810.e6.doi:10.1016/j.immuni.2025.01.016.Epub2025Feb25.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>