5-Methyltetrahydrofolic-acid-d4-5-Methyl-THF-d-sub-4-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE5-Methyltetrahydrofolicacid-d4Cat.No.:HY-113046S2CASNo.:461426-39-1Synonyms:5-MethylTHF-d4;5-MTHF-d4分⼦式:C₂₀H₂₁D₄N₇O₆分⼦量:463.48作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite作⽤通路:Others;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性5-Methyltetrahydrofolicacid-d4(5-MethylTHF-d4)氘代标记的5-Methyltetrahydrofolicacid(HY-113046)。5-Methyltetrahydrofolicacid(5-MethylTHF)体内叶酸的主循环形式，参与多种⽣物化学反应。5-Methyltetrahydrofolicacid通过增加低密度脂蛋⽩处理的内⽪细胞中内⽪素-1(ET-1)的产⽣，来调节⼼⾎管功能，可⽤于⼼⾎管疾病的研究。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].WrightAJ,etal.Comparisonof(6S)-5-methyltetrahydrofolicacidv.folicacidasthereferencefolateinlonger-termhumandietaryinterventionstudiesassessingtherelativebioavailabilityofnaturalfoodfolates:comparativechangesinfolatestatusfollowinga16-weekplacebo-controlledstudyinhealthyadults.BrJNutr.2010Mar;103(5):724-9.[2].Ronco,etal."5-methyltetrahydrofolicacidstimulatesendothelin-1productioninlowdensitylipoprotein-treatedhumanendothelialcells."Nutrition,MetabolismandCardiovascularDiseases17.3(2007):188-194.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955