BMS-754807-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBMS-754807(Standard)Cat.No.:HY-10200RCASNo.:1001350-96-4分⼦式:C₂₃H₂₄FN₉O分⼦量:461.49作⽤靶点:ReferenceStandards;IGF-1R;InsulinReceptor作⽤通路:Others;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性BMS-754807(Standard)BMS-754807(HY-10200)的分析标准品。本产品⽤于研究及分析应⽤。BMS-754807有效、可逆的IGF-1R/IR抑制剂，其IC50值分别为1.8和1.7nM，Ki值均⼩于2nM。BMS-754807同时也抑制Met，RON，TrkA，TrkB，AurA和AurB的活性，IC50IC50&TargetIC50:1.7nM(IR),1.8nM(IGF-1R),4nM(TrkB),6nM(Met),7nM(TrkA),9nM(AurA),25nM(AurB),44nM(RON)[1]REFERENCES[1].CarboniJM,etal.BMS-754807,asmallmoleculeinhibitorofIGF-1R/IR.MolCancerTher,2009,8(12),3341-3349.[2].WittmanMD,etal.Discoveryofa2,4-disubstitutedpyrrolo[1,2-f][1,2,4]triazineinhibitor(BMS-754807)ofIGF-1Rkinaseinclinicaldevelopment.JMedChem,2009,52(23),7360-7363.[3].KolbEA,etal.Initialtesting(stage1)oftheIGF-1receptorinhibitorBMS-754807bythepediatricpreclinicaltestingprogram.PediatrBloodCancer,2011,56(4),595-603.[4].FranksSE,etal.BMS-754807iscytotoxictonon-smallcelllungcancercellsandenhancestheeffectsofplatinumchemotherapeuticsinthehumanlungcancercelllineA549.BMCResNotes.2016Mar1;9:134.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: