CUDC-101-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECUDC-101(Standard)Cat.No.:HY-10223RCASNo.:1012054-59-9分⼦式:C₂₄H₂₆N₄O₄分⼦量:434.49作⽤靶点:ReferenceStandards;EGFR;HDAC作⽤通路:Others;JAK/STATSignaling;ProteinTyrosineKinase/RTK;CellCycle/DNADamage;Epigenetics储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性CUDC-101(Standard)CUDC-101(HY-10223)的分析标准品。本产品⽤于研究及分析应⽤。CUDC-101⼀种⾼效的HDAC、EGFR和HER2抑制剂，对应的IC50值分别为4.4、2.4和15.7nM。CUDC-101⼀种点击化学试剂。它含有Alkyne团，可以和含有Azide团的分⼦发⽣铜催化的叠氮-炔环加成反应(CuAAc)。IC50&TargetIC50:4.4nM(HDAC),2.4nM(EGFR),and15.7nM(HER2)[1]REFERENCES[1].XiongCaietalDiscoveryof7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide(CUDC-101)asaPotentMulti-ActingHDAC,EGFR,andHER2InhibitorfortheTreatmentofCancerJ.Med.Chem.,2010,53(5),pp2000–2009[2].SunH,etal.CUDC-101,aNovelInhibitorofFull-LengthAndrogenReceptor(flAR)andAndrogenReceptorVariant7(AR-V7)Activity:MechanismofActionandInVivoEfficacy.HormCancer.2016Jun;7(3):196-210.[3].ZhangL,etal.DualinhibitionofHDACandEGFRsignalingwithCUDC-101inducespotentsuppressionoftumorgrowthandmetastasisinanaplasticthyroidcancer.Oncotarget.2015Apr20;6(11):9073-85.[4].LaiCJ,etal.CUDC-101,amultitargetedinhibitorofhistonedeacetylase,epidermalgrowthfactorreceptor,andhumanepidermalgrowthfactorreceptor2,exertspotentanticanceractivity.CancerRes.2010May1;70(9):3647-56.Epub2010Apr13.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58