Ganglioside-GT1b-bovine-trisodium-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGangliosideGT1b(bovine)trisodiumCat.No.:HY-175073分⼦式:C₉₅H₁₆₂N₅Na₃O₄₇分⼦量:2195.28作⽤靶点:Toll-likeReceptor(TLR);InterleukinRelated作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性GangliosideGT1bbovinetrisodium⼀种三唾液酸神经节苷脂。GangliosideGT1bbovinetrisodium与A型⾁毒杆毒素(BTxA)、BTxA重链和破伤风毒素结合，IC50值分别为11、0.74和7.2μM。GangliosideGT1bbovinetrisodium在脊髓微胶质细胞中可作为TLR2激动剂，导致微胶质激活、促炎因⼦表达上升和痛觉敏感性增加。GangliosideGT1bbovinetrisodium可降低⼈外周⾎单核细胞(PBMC)中IL-6、IL-10、IgG、IgM和IgA的产⽣。GangliosideGT1bbovinetrisodium在神经细胞模型中能提升细胞外⾕氨酸⽔平。GangliosideGT1bbovinetrisodium可⽤于免疫系统疾病、神经系统疾病等领域的研究。REFERENCES[1].LimH,etal.GT1bfunctionsasanovelendogenousagonistoftoll-likereceptor2inducingneuropathicpain.EMBOJ.2020Mar16;39(6):e102214.[2].SchengrundCL,etal.BindingofbotulinumandtetanusneurotoxinstogangliosideGT1bandderivativesthereof.JNeurochem.1991Sep;57(3):1024-32.[3].EricksonKD,etal.GangliosideGT1bisaputativehostcellreceptorfortheMerkelcellpolyomavirus.JVirol.2009Oct;83(19):10275-9.[4].KandaN,etal.GangliosideGT1bsuppressesimmunoglobulinproductionbyhumanperipheralbloodmononuclearcells.Immunology.1999Apr;96(4):628-33.[5].WatanabeS,etal.InvolvementofgangliosideGT1binglutamatereleasefromneuroblastomacells.NeurosciLett.2012May31;517(2):140-3.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559