KT-474-hydrochloride-KYM-001-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEKT-474hydrochlorideCat.No.:HY-145483ACASNo.:2751703-31-6Synonyms:KYM-001hydrochloride;PROTACIRAK4degrader-7hydrochloride分⼦式:C₄₄H₅₀ClF₂N₁₁O₆分⼦量:902.39作⽤靶点:PROTACs;IRAK;Apoptosis作⽤通路:PROTAC;Immunology/Inflammation;Apoptosis储存⽅式:Storeatroomtemperature,keepdryandcool*Insolvent:-80°C,6months;-20°C,1month(Storeatroom

temperature,keepdryandcool)BIOLOGICALACTIVITY⽣物活性KT-474(KYM-001;PROTACIRAK4degrader-7)hydrochloride⼀种具有⼝服活性的PROTACIRAK4降解剂，具有抗肿瘤效果。KT-474抑制细胞周期并诱导了细胞凋亡(apoptosis)。KT-474在MYD88-突变ABCDLBCL的异种移植模型中诱导肿瘤消退。KT-474⼀种点击化学试剂，它含有炔，可以与含有叠氮的分⼦进⾏铜催化的叠氮-炔环加成(CuAAc)。户使⽤本产品发表的科研⽂献•AnalChem.2025Dec2;97(47):26097-26107.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].NelloMainolfi,etal.Irakdegradersandusesthereof.PatentWO2020113233A1.[2].AckermanL,etal.IRAK4degraderinhidradenitissuppurativaandatopicdermatitis:aphase1trial.NatMed.2023Dec;29(12):3127-3136.[3].JosephF.Kelleher,etal.AbstractLB-272:KYM-001,afirst-in-classoralIRAK4proteindegrader,inducestumorregressioninxenograftmodelsofMYD88-mutantABCDLBCLaloneandincombinationwithBTKinhibition.CancerRes(2019)79(13_Supplement):LB-272.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: