L-5-Hydroxytryptophan-d3-hydrate-L-5-HTP-d-sub-3-sub-hydrate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEL-5-Hydroxytryptophan-d3hydrateCat.No.:HY-B1716SASynonyms:L-5-HTP-d3hydrate;Oxitriptan-d3hydrate分⼦式:C₁₁H₁₁D₃N₂O₄分⼦量:241.26作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite作⽤通路:Others;MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性L-5-Hydroxytryptophan-d3(L-5-HTP-d3)hydrateL-5-Hydroxytryptophan(HY-B1716)的氘代物。L-5-Hydroxytryptophan-d3L-5-Hydroxytryptophan的氘代物。L-5-Hydroxytryptophan(L-5-HTP)⼀种天然氨酸和膳⾷补充剂，可作为抗抑郁剂、⾷欲抑制剂和睡眠辅助剂，神经递质⾎素的前体，利⾎平(reserpine)的拮抗剂。L-5-Hydroxytryptophan(L-5-HTP)可⽤于纤维肌痛症、肌阵挛、偏头痛和⼩脑共济失调的研究[2][3][4][5]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].ARVIDCARLSSON,etal.3,4-Dihydroxyphenylalanineand5-HydroxytryptophanasReserpineAntagonists.Nature180,page1200(1957).[3].CarusoI,etal.Double-blindstudyof5-hydroxytryptophanversusplacebointhetreatmentofprimaryfibromyalgiasyndrome.JIntMedRes.1990May-Jun;18(3):201-9.[4].ThalLJ,etal.TreatmentofmyoclonuswithL-5-hydroxytryptophanandcarbidopa:clinical,electrophysiological,andbiochemicalobservations.AnnNeurol.1980Jun;7(6):570-6.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[5].BoiardiA,etal.5-OH-Tryptophaneinmigraine:clinicalandneurophysiologicalconsiderations.JNeurol.1981;225(1):41-6.[6].TrouillasP,etal.Improvementofcerebellarataxiawithlevorotatoryformof5-hydroxytryptophan.Adouble-blindstudywithquantifieddataprocessing.ArchNeurol.1988Nov;45(11):1217-22.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: