Quisinostat-hydrochloride-JNJ26481585-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEQuisinostathydrochlorideCat.No.:HY-15433BCASNo.:1083078-98-1Synonyms:JNJ26481585hydrochloride分⼦式:C₂₁H₂₇ClN₆O₂分⼦量:430.93作⽤靶点:HDAC;Autophagy作⽤通路:CellCycle/DNADamage;Epigenetics;Autophagy储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Quisinostat(JNJ-26481585)hydrochloride⼀种⾼效的、具有⼝服活性的pan-HDAC抑制剂(HDACi)，对HDAC1、HDAC2、HDAC4、HDAC10、HDAC11作⽤的IC50值范为0.11-0.64nM。Quisinostathydrochloride具有⼴泛的抗肿瘤活性。Quisinostathydrochloride在成神经细胞瘤中能诱导⾃噬(autophagy)。IC50&TargetHDAC1HDAC2HDAC4HDAC100.11nM(IC50)0.33nM(IC50)0.64nM(IC50)0.46nM(IC50)HDAC11HDAC3HDAC5HDAC80.37nM(IC50)4.86nM(EC50)3.69nM(IC50)4.26nM(IC50)HDAC9HDAC6HDAC732.1nM(IC50)76.8nM(IC50)119nM(IC50)户使⽤本产品发表的科研⽂献•CancerCell.2024Oct14;42(10):1729-1746.e8.•NatCommun.2024Jul2;15(1):5570.•NatCommun.2024Jul2;15(1):5570.•NatCommun.2020Apr14;11(1):1792.•ExpHematolOncol.2019Nov15;8:30.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESeemorecustomervalidationsonwww.MedChemEREFERENCES[1].VamsiKrishnaKommalapati,etal.InhibitionofJNJ-26481585-mediatedautophagyinducesapoptosisviaROSactivationandmitochondrialmembranepotentialdisruptioninneuroblastomacells.MolCellBiochem.2020May;468(1-2):21-34.[2].ArtsJ,etal.JNJ-26481585,anovel"second-generation"oralhistonedeacetylaseinhibitor,showsbroad-spectrumpreclinicalantitumoralactivity.ClinCancerRes.2009Nov15;15(22):6841-51.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58