R-Colchicine-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(R)-ColchicineCat.No.:HY-W741136CASNo.:75520-89-7分⼦式:C₂₂H₂₅NO₆分⼦量:399.44作⽤靶点:DrugIsomer;Microtubule/Tubulin;NOD-likeReceptor(NLR);Autophagy;Apoptosis作⽤通路:Others;CellCycle/DNADamage;Cytoskeleton;Immunology/Inflammation;Autophagy;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性(R)-ColchicineColchicine(HY-16569)的R型异构体。Colchicine⼀种具有⼝服活性的⽣物碱，⼀种有效的微管蛋⽩抑制剂和微管破坏剂。Colchicine抑制微管聚合，IC50为3nM。Colchicine也α3⽢氨酸受体(GlyR)的竞争性拮抗剂。Colchicine通过抑制NLRP3炎症⼩体的激活来预防⾮甾体抗炎药(NSAID)引起的⼩肠损伤。Colchicine具有⼴泛的抗炎、免疫抑制和强抗纤维化作⽤，同时具有⽤于痛风性关节炎研究的潜⼒。REFERENCES[1].BonfocoE,etal.Colchicineinducesapoptosisincerebellargranulecells.ExpCellRes.1995May;218(1):189-200.[2].HastieSB.Interactionsofcolchicinewithtubulin.PharmacolTher.1991;51(3):377-401.[3].YuanjunTang,etal.NetworkPharmacology-BasedInvestigationandExperimentalExplorationoftheAntiapoptoticMechanismofColchicineonMyocardialIschemiaReperfusionInjury.FrontPharmacol.2021Dec16:12:804030.[4].OtaniK,etal.ColchicinepreventsNSAID-inducedsmallintestinalinjurybyinhibitingactivationoftheNLRP3inflammasome.SciRep.2016Sep2;6:32587.[5].CarolaMuñoz-Montesino,etal.InhibitionoftheGlycineReceptoralpha3FunctionbyColchicine.FrontPharmacol.2020Jul30;11:1143.[6].TorinHuzilJ,etal.ComputationaldesignandbiologicaltestingofhighlycytotoxiccolchicineringAmodifications.ChemBiolDrugDes.2010Jun;75(6):541-50.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58