Saccharolactone-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESaccharolactoneCat.No.:HY-153875CASNo.:389-36-6分⼦式:C₆H₈O₇分⼦量:192.12作⽤靶点:β-glucuronidase;CytochromeP450作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Saccharolactone⼀种强效的⼝服活性β-葡萄糖醛酸酶(β-glucuronidase)抑制剂。糖内酯可显著降低⼤⿏胆汁中胆汁内性β-葡萄糖醛酸酶的活性。Saccharolactone可在体外稳定葡萄糖醛酸苷代谢物。Saccharolactone也CYP1A2、2D6、3A4和2C8同⼯酶的强效抑制剂(IC50<4mM)[1][2][3]。IC50&TargetCYP1A2CYP2D6CYP3A4CYP2C850)50)50)50)户使⽤本产品发表的科研⽂献•JEnzymeInhibMedChem.2024Dec;39(1):2387415.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].MacfadyenA,etal.D-glucaro-1,4-lactone:itsexcretioninthebileandurineandeffectonthebiliarysecretionofbeta-glucuronidaseafteroraladministrationinrats.Hepatology.1989Apr;9(4):552-6.[2].BeheraD,etal.EffectofSaccharolactoneonCYP-mediatedMetabolismofXenobiotics.DrugMetabBioanalLett.2023;16(2):121-132.[3].OlesonL,etal.Effectofthebeta-glucuronidaseinhibitorsaccharolactoneonglucuronidationbyhumantissuemicrosomesandrecombinantUDP-glucuronosyltransferases.JPharmPharmacol.2008Sep;60(9):1175-82.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02