SAP15-acetate-Synthetic-anti-inflammatory-peptide-15-acetate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESAP15acetateCat.No.:HY-P10462ASynonyms:Syntheticanti-inflammatorypeptide15acetate分⼦式:C₆₈H₁₃₁N₃₁O₁₈S₃·xC₂H₄O₂Sequence:Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-LysSequenceShortening:GKCSTRGRKCCRRKK作⽤靶点:HDAC;NF-κB作⽤通路:CellCycle/DNADamage;Epigenetics;NF-κB储存⽅式:Sealedstorage,awayfrommoisturePowder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1month溶解性数据体外实验H2O:≥100mg/mL*"≥"meanssoluble,butsaturationunknown.请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性SAP15(Syntheticanti-inflammatorypeptide15)acetate⼀种由⼈类β-防御素3设计的15个氨酸组成的合成抗炎肽。SAP15acetate具有穿透细胞的能⼒，并能够诱导细胞内炎症的下调。SAP15acetate通过抑制HDAC5的磷酸化，从⽽减少NF-κBp65的磷酸化，进⽽抑制炎症反应。SAP15acetate能够抑制LPS(HY-D1056)诱导的巨噬细胞中HDAC5和NF-κBp65的磷酸化。SAP15acetate处理增加了LPS诱导的软⾻细胞中aggrecan和II型胶原的表达，并减少了⾻钙素的表达。SAP15acetate可⽤于⽣物材料的炎症调节和抗炎的研究[1]。IC50&TargetHDAC5NF-κBp651/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEREFERENCES[1].LeeJY,etal.Engineeredsyntheticcellpenetratingpeptidewithintracellularanti‐inflammatorybioactivity:Aninvitroandinvivostudy[J].JournalofBiomedicalMaterialsResearchPartA,2021,109(10):2001-2016.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax