α-Galactosylceramide-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEα-Galactosylceramide(Standard)Cat.No.:HY-102022RCASNo.:158021-47-7分⼦式:C₅₀H₉₉NO₉分⼦量:858.34作⽤靶点:ReferenceStandards;TransmembraneGlycoprotein;InterleukinRelated;CD1作⽤通路:Others;Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性α-Galactosylceramide(Standard)α-Galactosylceramide(HY-102022)的分析标准品。本产品⽤于研究及分析应⽤。α-Galactosylceramide(α-GalCer)⼀种合成的糖脂，具有抗肿瘤和免疫刺激作⽤。α-Galactosylceramide⼀种⾮常有效的NKT细胞激动剂，可与CD1d有效结合。α-Galactosylceramide与CD1d的复合物可与NKT细胞的T细胞IC50&TargetNKTcell[3]REFERENCES[1].GodfreyDI,etal.Goingbothways:immuneregulationviaCD1d-dependentNKTcells.JClinInvest.2004Nov;114(10):1379-88.[2].MoritaM,etal.PracticalTotalSynthesisof(2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol,theAntitumorialandImmunostimulatoryα-Galactosylcer-amide,KRN7000.BiosciBiotechnolBiochem.1996Jan;60(2):288-92.[3].KikuchiA,etal.Invitroanti-tumouractivityofalpha-galactosylceramide-stimulatedhumaninvariantValpha24+NKTcellsagainstmelanoma.BrJCancer.2001Sep1;85(5):741-6.[4].MasahiroMorita,etal.Structure-ActivityRelationshipof.alpha.-GalactosylceramidesagainstB16-BearingMice.J.Med.Chem.1995,38,12,2176-2187.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: