【关节软骨缺损及修复研究现状的文献综述11000字】

[35]。纳米羟基磷灰石增强聚乙烯醇凝胶复合材料被认为是一种很有前途的生物材料，特别是作为关节软骨修复材料。本文拟制备一种聚乙烯醇/明胶/纳米羟基磷灰石（PVA/Gel/n-HA）复合凝胶材料，三者分别为一种无机相、纳米级别的物质和两种有机相的高聚物，为使三相分散均匀良好，本文采用了物理共混法和冷冻解冻法来制备具有三维多孔结构的PVA/Gel/n-HA复合水凝胶，并在含水率、溶胀率、红外吸收光谱和扫描电子显微镜四个方面对其性能进行了测试，以确保其具有作为关节软骨替代物的最基本的性质。参考文献HuJ,AthanasiouKA.StructureandFunctionofArticularCartilage[M].HumanaPress,2003.ZhaoW,XingJ,YangC,etal.Degradablenaturalpolymerhydrogelsforarticularcartilagetissueengineering[J].JournalofChemicalTechnology&Biotechnology,2013,88(3).晏丹，周广东，曹谊林。关节软骨生化结构及其与力学性能关系研究进展[J].上海交通大学学报(医学版),2009,29(003):341-345.段王平，孙振伟，卫小春。关节软骨中最基本的解剖功能结构：软骨单位[J].中国组织工程研究与临床康复,2010.马立恒，刘斯润，关节软骨的结构与生物力学的关系及MR成像[J].国际医学放射学杂志,2006,29(2):123-126.MowVC,KueiSC,LaiWM,etal.BiphasicCreepandStressRelaxationofArticularCartilageinCompression:TheoryandExperiments[J].JournalofBiomechanicalEngineering,1980,102(1):73-84.MowVC,RatclifFeA,PooleAR.Cartilageanddiarthrodialjointsasparadigmsforhierarchicalmaterialsandstructures[J].Biomaterials,1991,13(2):67-97.KovachIS,AthanasiouKA.Small-angleHeNelaserlightscatterandthecompressivemodulusofarticularcartilage[J].JournalofOrthopaedicResearch,1997,15(3):437-441.HouJS,MowVC,LaiWM,etal.Ananalysisofthesqueeze-filmlubricationmechanismforarticularcartilage.[J].JournalofBiomechanics,1992,25(3):247-259.SwannDA,SlayterHS,SilverFH.Themolecularstructureoflubricatingglycoprotein-I,theboundarylubricantforarticularcartilage[J].JournalofBiologicalChemistry,1981,256(11):5921-5925.MansourJM,MowVC.Thepermeabilityofarticularcartilageundercompressivestrainathighpressures[J].TheJournalofBoneandJointSurgery,1976,58(4):509-516.WalkerPS,DowsonD,MDLongfield,etal."Boostedlubrication"insynovialjointsbyfluidentrapmentandenrichment.[J].AnnalsoftheRheumaticDiseases,1968,27(6):512-520.MakrisEA,GomollAH,MalizosKN,etal.Repairandtissueengineeringtechniquesforarticularcartilage[J].NatureReviewsRheumatology,2015,11(1):21-34.HunzikerE.Articularcartilagerepair:aretheintrinsicbiologicalconstraintsunderminingthisprocessinsuperable?[J].OsteoarthritisCartilage,1999,7(1):15-28.LoriesRJ,LuytenFP.Thebone–cartilageunitinosteoarthritis[J].NatureReviewsRheumatology,2011,7(1):43.MoranCJ,Pascual-GarridoC,ChubinskayaS,etal.RestorationofArticularCartilage[J].JournalofBone&JointSurgery-americanVolume,2014,96(4):336-344.王彦明，余家阔，于长隆等。关节镜下微骨折术修复膝关节软骨全层缺损的临床疗效观察[J].中国运动医学杂志,2006,25(006):651-654,724.Er-YuanChuang,Chih-WeiChiang,Pei-ChunWong,Chih-HwaChen,JunLiu.HydrogelsfortheApplicationofArticularCartilageTissueEngineering:AReviewofHydrogels[J].AdvancesinMaterialsScienceandEngineering,2018,2018.MeiL,XinZ,ChaoM,etal.Injectablehydrogelsforcartilageandbonetissueengineering[J].BoneResearch,2017,5(2):75-94.PinkasO,DGoder,NoyvirtR,etal.Structuringofcompositehydrogelbioadhesivesanditseffectonpropertiesandbondingmechanism[J].ActaBiomaterialia,2017,51:125-137.HuW,WangZ,XiaoY,etal.Advancesincrosslinkingstrategiesofbiomedicalhydrogels[J].BiomaterialsScience,2019.DelValleLuísJ,DíazAngélica,PuiggalíJordi.HydrogelsforBiomedicalApplications:Cellulose,Chitosan,andProtein/PeptideDerivatives.[J].Gels(Basel,Switzerland),2