雨课堂学堂在线学堂云《Medical Immunology（中国医科大学）》单元测试考核答案

MedicalImmunology第1题Thattheimmunecellssensingandeliminatingthealteredcellsiscalled().AImmunologicalbalancingBImmunologicalmemoryCImmunologicalsurveillanceDImmunologicalhomeostasisEImmunologicaldefense第2题()hastheabilitytoproduceimmunememory.ABasophilBNeutrophilCEosinophilDMonocyteETcell第3题Whathappenstoapathogenasitbecomesattenuated?()AItbecomesmoredangeroustothehost.BItgetssmaller.CItbecomestoooldtoinitiatetheimmuneresponse.DIthasweakenedvirulence.EItbecomesmoreinvasivetothehost.第4题Thescientistwhodevelopedcowpoxasvaccinetoprotecthumanfromgettingsmallpoxis().AEdwardJennerBLouisPasteurCEmilvonBehringDRobertKochEElieMetchnikoff第1题Variableregionsarelocatedonthe(）.ABothlightchainsofimmunoglobulinBBothheavychainsofimmunoglobulinCOnelightchainandoneheavychainofimmunoglobulinDBothlightchainsandheavychainsofimmunoglobulinEOnlylightchainsofimmunoglobulin第2题()aregeneratedwhenIgGisdigestedbypapain.ATwoFabandoneFcBOneF(ab’)2andoneFc’COneF(ab’)2DOneFabandoneFcETwoFab第3题IfapersonhadamutationinthegeneencodingJ(joining)chains,whichofthefollowingclassesofantibodiescouldNOTbeproduced?()AIgAandIgMBIgAandIgGCIgGandIgEDIgDandIgEEIgGandIgM第4题Oneofthedifferencesbetweenanormalimmuneresponseandallergicreactionisthelevelof()AIgMBIgECIgGDIgAEIgDTestofPart3第1题TowhichofthefollowingsisMBLmoststructurallysimilar?()AC3bBBbCC1qDC5bEC1r第2题WhichofthefollowingcomplementfixationpathwayscanbeinitiatedbyasolubleC3convertase?()AAlternativeBClassicalCLectinDAlternativeandclassicalEAlternativeandlectin第3题WhichofthefollowingisINCORRECTinregardtotheclearingofthemicrobefromthehostmediatedbyCR1bindingofcomplement-opsonizedmicrobes?()AItpromotesthephagocytosisofopsonizedmicrobesbyleukocytesBItinitiatesthesecretionofproinflammatorycytokinesCItmediatesthephagocytosisofC3b-opsonizedpathogenbymacrophagesDItpromotesthecaptureofmicrobesbyredbloodcellsEItprovidesthesignalforTcellsactivation第4题WhichofthefollowingsisNOTthebiologicalconsequenceofcomplementactivation?()ATargetcelllysisBRemovalofimmunecomplexCNeutralizationoftoxinDInflammationEOpsonizationTestofPart4第1题()isimportantforBcellstosampletheantigensinthelymphnodes.ANaturalkillerBSubcapsularsinusmacrophagesCNaïveTcellsDActivatedTcellsEHelperTcells第2题Whichofthefollowingsiscorrectinregardtothehumoralimmuneresponse?()AThehumoralimmuneresponseusuallyoccursintheinfectionlocation.BThehumoralimmuneresponsetoTDantigensdoesnotrequiretheinvolvementofTcells.CDuringaprimaryhumoralresponse,IgMissecretedinitially,oftenfollowedbyaswitchtoanincreasingproportionofIgG.DTheactivationofTcellsrequirestwosignals,whereasBcellsactivationdoesnot.ETandBcellsrecognizethesameepitopeonthesameantigen.第3题DuringthehumoralimmuneresponsetoTD-Ag,ThareNOTinvolvedintheprocessof().AAffinitionofmaturationBSpecificcytotoxicitytoantigensCSurvivalofBcellsDActivationofBcellsEClassswitchingofIg第4题WhichofthefollowingdescriptionsisINCORRECT?()ATheaffinitymutationofantibodyismainlytheresultofsomatichypermutationandselectioninthegeminalcenter.BClassswitchingallowstheselectedBcellstoproduceantibodieswithavarietyofeffectorfunctions.CFolliculardendriticcellsandTfollicularhelpersareimportantforBcellstoproduceamoreeffectiveantibodyresponse.DFolliculardendriticcellsarerichlyendowedwithbothFcreceptorsandcomplementreceptorstoaccumulatetheantigensforBcellsbinding.EThegenerationofantibodydiversitymainlyoccursinthegerminalcenter.TestofPart5第1题WhichofthefollowingisNOTahumanMHCgene?____AABCCDPDDREK第2题YourchancesofhavingthesameMHChaplotypeasyoursiblingare:____A1:1B1:2C1:4D1:8E1:16第3题MHCImoleculesarefoundinallcellsofourbodyexcept____ADendriticcellsBTcellsCmaturalredbloodcellsDlivercells第4题Atmost,howmanydifferentclassicalclassIMHCmoleculesarethereoneachnucleatedcellinahuman?____AOneBTwoCThreeDSix第5题HLAdeterninantscanbeusedforonesetofmarkersinpaternitytesting.Giventhefollowingphenotypes,whichofthepotentialfathersismostlikelytheactualbiologicalfather____?ThephenotypefortheoffspringisHLA-A:A3,33;HLA-B:B54,59;HLA-C:C5,8ThephenotypeforthebiologicalmotherisHLA-A:A3,11;HLA-B:B59,78;HLA-C:C8,8AHLA-A:A3,33;HLA-B:B56,27;HLA-C:C5,5BHLA-A:A11,33;HLA-B:B54,27;HLA-C:C5,6CHLA-A:A11,33;HLA-B:B59,26;HLA-C:C6,8DHLA-A:A3,3;HLA-B:B54,27;HLA-C:C5,5TestofPart6第1题WhichofthefollowingrepresentstheearlieststageinT-celldevelopment?____ADPBDNCSP-CD4DSP-CD8EMatureTcell第2题AnaïveTcellreferstoaTcellthat:____AdoesnotexpressCD4+orCD8+BhasnotleftthebonemarrowChasnotyetencounteredanantigenDisnotmatureEresidesinthethymus第3题IthasbeenlearnedinseveralexperimentalsystemsthatproliferationanddifferentiationofTlymphocytesinresponsetotumorcellsislowbecausetumorcellslackthenecessaryco-stimulatorymoleculesforlymphocyteactivation.Ifmelanomacellsfromapatientwereinducedtoexpresstheseco-stimulatorymoleculesbytransfection,productionofaneffectiveanti-tumorresponsemightoccur.Whichofthefollowingmolecules____wouldbethebestcandidatefortransfectionoftumorcellstoachievethisend?AB7BCD2CCD4DCD28ELFA-1TestofPart7第1题Whichofthefollowingstatementscorrectlydescribestheexogenouspathwayofantigenprocessing?____AEnablestheactivationofCD4+TcellsBGeneratesantigensfromcytoplasmicpathogensCInvolvesthegenerationofpeptidesbyproteasomeactivityDRequirestheactionofTransporterassociatedwithantigenprocessing(TAP)tomobilisesmallcytosolicpeptidesintotheERlumen第2题Whichofthefollowingisanexampleofcross-presentation?____AAnendogenouspeptidebeingpresentedonMHCclassIBAnexogenouspeptidebeingpresentedonMHCclassICAnendogenouspeptidebeingpresentedonMHCclassIIDAnexogenouspeptidebeingpresentedonMHCclassIIEAB-cellantigenbeingpresentedtoaTcell第3题Forpathogenpeptidestobeseenasforeign,theymustbedisplayedonaTcellinthecontextofa/an:____AB-cellmarkerBCDmoleculeCIgMmoleculeDMHCpeptideEpattern-recognitionreceptormolecule第4题ThecellsthatdisplaypeptidesassociatedwithclassIIMHCmoleculestoCD4+thecellsarecalledantigenpresentationcells.Inthefollowingcells,____arethenon-professionalantigenpresentingcells?AMacrophagesBDendriticcellsCFibroblastsDBlymphocytes第5题IthasbeenlearnedinseveralexperimentalsystemsthatproliferationanddifferentiationofTlymphocytesinresponsetotumorcellsislowbecausetumorcellslackthenecessaryco-stimulatorymoleculesforlymphocyteactivation.Ifmelanomacellsfromapatientwereinducedtoexpresstheseco-stimulatorymoleculesbytransfection,productionofaneffectiveanti-tumorresponsemightoccur.Whichofthefollowingmolecules____wouldbethebestcandidatefortransfectionoftumorcellstoachievethisend?AB7BCD2CCD4DCD28ELFA-1TestofPart8第1题Theroleofcell-mediatedimmunityis:____Atoeliminatetheoutercellular