心肌细胞电生理.ppt

1、Electricalactivitiesofheart,Workingcell,Autorhythmiccell,excitability,conductivity,contractility,excitability,conductivity,contractility,automaticity,atrium,AVnode,preferentialpathway,BundleofHis,Leftandrightbranch,Purkinjefibers,Ventricles,SAnode,AVnode,BundleofHis,Purkinjefibers,SAnode,Dominantpac

2、emaker,Latentpacemaker,ectopicpacemaker,1Electricalactivitiesofworkingcells,(1)Restingpotential(RP),a.mostpermeabletoK+,relativelyimpermeabletootherions,b.C0Ci,K+,C0Ci,Cl-,C0Ci,Ito1andIto2,INa,ICaandIK,1,0,2,IKandIK1,3,4,IK1，PumpandNCX,Na+channel,Ito1channelandCACC,L-Ca2+channelandIKchannel,IK1andIK

3、channel,IK1channel,APofatrialmyocytescomparedtoventricularcells,moreK+channel,Rapidrepolarization,Absenceofphase2,2Electricalactivitiesofautorhythmiccell,Pcells,BundleofHisandPurkinjefiber,Purkinjecell,SAnode,Maximumdiastolicpotential,(1)ElectricalactivitiesofPcell,Absence:IK1channel,Na+channel,Itoc

4、hannel,Presence:,Ifchannel,IKchannel,T-Ca2+channel,NCX,-50mv-100mv:deactivation,-60mv-100mV:activation,-50mv:activation,ActivatedbyCa2+i,Hyperpolarization,Transient,L-Ca2+channel,-40mv:activation,depolarization,-50-60mV40mV,-40mV0mV,L-Ca2+channelopen,Ca2+inflow,repolarization,-0mV-50-60mV,IKchannel,K+outflow,Spontaneousdepolarization,Spontaneousdepolarization,Ifchannel,IKchannel,T-Ca2+channel,NCX,-50mv-100mv:deactivation,-60mv-100mV:activation,-50mv:activation,ActivatedbyCa2+i,decrease,increase,increa