生物化学与分子生物学PPT图片素材-ScienceSl(1).ppt

Cholesterol Sterol Toolkit PregnenolonProgesteronAldosteron CortisolCorticosteroneAndrostendioneTestosteron Estriol17-Estradiol1, 25-DihydroxycholecalciferolCholic acid Covalent modification of proteins Poly(ADP ribosyl) Polymerase (PARP) Poly(ADP ribosyl) polymerase (PARP) NAD Nicotinamide Poly(ADP ribosyl) polymerase (PARP) Poly(ADP ribosyl) chain elongation and branching Nicotinamide NAD NAD DNA polymerase DNA polymerase DNA polymerase Oligosacharyl transferase N-glycosylation pathway in ER Mann-P-Dolichol transferases Flippase Dolichol P Dolichol P P Dolichol P P Dolichol P P DolicholPP GlcNAc-P transferase GlcNAc transferase Dolichol P Dolichol P P Dolichol P P GDP-Mannosyl transferases Glc-P-Dolichol transferases Dolichol P Dolichol- pyrophofphatase Cytosol ER 40S 60S UTP CTP TMP Pyrimidine Nucleotide Interconversions UMP ATP ADP H2O UDP Nucleoside monophosphate kinase ATP ADP Nucleoside diphosphate kinase ATP ADP CTP synthase Ribonucleotide reductase deoxyUDP Nucleoside diphosphate phosphohydrolase deoxyUMP Thymidylate synthase N5,N10-MethyleneTHF DHF TTP Nucleoside monophosphate kinase Nucleoside diphosphate kinase Myo-Inositol-3-phosphate Ins(3)P1 Biosynthesis and metabolism of phosphoinositides Glucose 6-pgosphate Ins(3)P1 synthase Ins(3)P1 phosphatase Myo-Inositol Ins PtdIns synthase PtdIns Myo-inositol kinase PtdIns-4-P PtdIns 4-kinase PtdIns 5-kinase PtdIns-4,5-P2 PI3K PtdIns-3,4,5-P3 PLC PLC PI3K PtdIns-3,4-P2 Ins-1,3,4-P3 Ins-1,3,4,5-P4Ins-1,4,5-P3 PLC PTEN PTEN Ins-1,4-P3 PTEN PTEN Fatty acid synthase -ketoacyl ACP-synthase Fatty acids synthesis Acetyl CoA carboxylase ATP ADP + Pi Acetyl CoA Malonyl CoA Citrate Oxaloacetate ATP ADP + Pi Citrate lyase Acetyl transacylase Malonyl transacylase Pantetheine -ketoacyl ACP-reductase Pantetheine Pantetheine -hydroxyacyl ACP-dehydratase Pantetheine Enoyl-ACP reductase Pantetheine NADPH NADP NADPH NADP Cholesterol de novo synthesis I Isoprenyl formation Acetoacetyl-CoA Thiolase HMG-CoA synthase Mevalonate 3-Hydroxy-3- methylglutaryl-CoA Mevalonate kinase Phosphomevalonate kinase Mevalonate- 5-pyrophospho decarboxylase 5-Phosphomevalonate 5-Pyrophosphomevalonate3-Isopentenylpyrophosphate 3, 3-Dimethylalylpyrophosphate Isomerase HMG-CoA reductase 2 NADPH 2 NADP ATP ADP ADP ATP ADP ATP Cholesterol Biosynthesis of bile acids 7-Hydroxycholesterol Sterol 7 hydroxylase CYP7A1 7-Hydroxy-4-cholesten-3-one 3-Hydroxy stroid dehydrogenase HSD3B7 7, 12-Dihydroxy-4-cholesten-3-one Sterol-12- hydroxylase CYP8B1 5-Cholestan-3, 7, 12-Triol Oxosteroid- 5-reductase AKR1D1 Sterol 27- hydroxylase CYP27A1 3, 7, 12-Trihydroxy-5-cholestanoic acid Cholic acid AKR1D1 AKR1C4 5-Cholestan-3, 7-diol 12-Deoxycholic acid 3-Hydroxy- steroid dehydrogenase AKR1C4 Biosynthesis of RNA RNA Polymerase Biosynthesis of DNA DNA Polymerase -oxidation Mitochondrial matrix Intermembrane space Palmitoyl carnitine Palmitoyl carnitine Palmitoyl CoA Palmitoyl CoA Trans 2 enolopalmitoyl CoA 3-Hydroxypalmitoyl CoA 3-Ketopalmitoyl CoA Myristoyl CoA Acetyl-CoA Palmitoyl CoA Palmitate Palmitoyl CoA ligase ATP AMP Carnitine acyltransferase I Carnitine Carnitine acyltransferase II Acyl CoA dehydrogenase Enoyl CoA hydratase 3-Hydroxyacyl CoA dehydrogenase Citric Acid Cycle FAD FADH2 NAD NADH Cytoplasm H2O Myo-Inositol-3-phosphate Ins(3)P1 Phospho-myo-inositol Toolkit 2 Myo-Inositol-3,4-diphosphate Ins(3,4)P2 Myo-Inositol-3,6-diphosphate Ins(3,6)P2 Myo-Inositol-3,4,6-triphosphate Ins(3,4,6)P3 Myo-Inositol-1,3,4-triphosphate Ins(1,3,4,)P3 Myo-Inositol-3,4,5,6-tetraphosphate Ins(3,4,5,6)P4 Myo-Inositol-1,4,5-triphosphate Ins(1,4,5)P3 Myo-Inositol-1,3,4,6-tetraphosphate Ins(1,3,4,6)P4 Myo-Inositol-1,3,4,5-tetraphosphate Ins(1,3,4,5)P4 Myo-Inositol-1,4,5,6-tetraphosphate Ins(1,4,5,6)P4 Myo-Inositol-1,2,3,4,6-pentaphosphate Ins(1,2,3,4,6)P5 Myo-Inositol-1,3,4,5,6-pentaphosphate Ins(1,3,4,5,6)P5 Myo-Inositol-1,2,3,4,5-pentaphosphate Ins(1,2,3,4,5)P5 Myo-Inositol-1,2,4,5,6-pentaphosphate Ins(1,2,4,5,6)P5 Myo-Inositol-1,2,3,4,5,6-hexaphosphate Ins(1,2,3,4,5,6)P6 (Phytic acid) Myo-Inositol-3-phosphate Ins(3)P1 Phospho-myo-inositol Toolkit Myo-Inositol-3,4-diphosphate Ins(3,4)P2 Myo-Inositol-3,6-diphosphate Ins(3,6)P2 Myo-Inositol-3,4,6-triphosphate Ins(3,4,6)P3 Myo-Inositol-1,3,4-triphosphate Ins(1,3,4,)P3 Myo-Inositol-3,4,5,6-tetraphosphate Ins(3,4,5,6)P4 Myo-Inositol-1,4,5-triphosphate Ins(1,4,5)P3 Myo-Inositol-1,3,4,6-tetraphosphate Ins(1,3,4,6)P4 Myo-Inositol-1,3,4,5-tetraphosphate Ins(1,3,4,5)P4 Myo-Inositol-1,4,5,6-tetraphosphate Ins(1,4,5,6)P4 Myo-Inositol-1,2,3,4,6-pentaphosphate Ins(1,2,3,4,6)P5 Myo-Inositol-1,3,4,5,6-pentaphosphate Ins(1,3,4,5,6)P5 Myo-Inositol-1,2,3,4,5-pentaphosphate Ins(1,2,3,4,5)P5 Myo-Inositol-1,2,4,5,6-pentaphosphate Ins(1,2,4,5,6)P5 Myo-Inositol-1,2,3,4,5,6-hexaphosphate Ins(1,2,3,4,5,6)P6 (Phytic acid) Glycogen Glycogenin 8-oxoguanine A common DNA lesions Toolkit I O6-methylguanine Uracil Thymine glycol 1, N6-ethenoadenine3-methyladenineCyclobutane pyrimidine dimers Photoadduct RiboseGlucuronateArabinoseFructoseGlucoseGalactose MannoseFucoseSialic AcidInositolD-AbequoseL-Rhamnose A carbohydrate toolkit PGH2 TXA2 TXB2 Bioactive lipids - Prostanoid