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病例讨论,第二季度 外科、手术室、放射科,病例概况,男性,41岁,因“反复间断咯血13年余,再发5个月,加重3天”入院 。 13年前无明显诱因咯血,起初为暗黑色血块,后为鲜红色血液,量不详,伴有轻咳,痰少,自服中药及休息后能自行止血,近2年发作减少,咯血量少,每年发作1-2次,常能自行缓解。5个月前咯血再发,量及次数较前增多,为鲜红色血液,2月前于广州医科大学第一附属医院住院诊治,考虑“肺结核后遗症”,经抗炎,止血化痰处理效果不佳,自动出院。于3天前症状加重,约一饭碗,为鲜红色血液,伴轻度头晕、心慌,伴刺激咳嗽,自觉全身发热 。 既往史、个人史无特殊。有吸烟史,饮酒史。家族史无特殊。 体格检查无阳性体征。,2012年11月9日广医呼研所胸部CT+肺动脉造影示: 1、肺动脉造影未见异常; 2、拟左下肺前内基底段肺静脉少量附壁血栓形成; 3、左上肺尖后段纤维性肺结核并含气不全。 4、两上肺、右下肺背段胸膜下多发肺大泡形成。纤支镜检查:支气管粘膜充血,未见狭窄及占位病灶。肝胆脾胰肾彩超未见异常。,2012年12月23日,血WBC 9.82109/L,中性粒细胞百分比78%,血红蛋白108/L,血小板正常。CRP12mg/L,ESR20mm/h。ALT35,AST29,GGT42,ALP72。GLU5.6,凝血四项与D-聚体:PT(凝血酶原时间)17.7,PT/R(凝血酶原比值)1.55,PTINR(凝血酶原国际比值)1.52,Fbg1.36,TT19.0,D-聚体0.06。肾功UREA2.76,CRE84.1,UA293。痰涂片:未发现抗酸杆菌,血清肺支原体抗体(-),结核杆菌抗体(-),急诊胸部CT平扫加肺动脉CTA未见异常。,经抗炎,止血处理2天效果不佳,咯血频繁,请耳鼻喉会诊,给予喉镜检查:咽喉炎。行鼻咽喉部MRI扫描未见异常。行胃镜检查未见异常。住院第三天再次行CT肺动脉造影并行肺动脉栓塞术,术后3小时咯血仍增多,继续微泵垂体后叶素等止血对症处理,住院16天出院。,一、病例特点,1、病程长,再次发作,突然加重。中青年,男性,反复间断咯血13年余,再发5月,加重3天; 2、病情重:咯血量较多,约一饭碗,为鲜红血液。 3、病情复杂:缺乏阳性体征,仅胸部CT检查及血液检查阳性,发病以来缺乏明确诊断。 4、病史不完整:缺乏详细治疗史、寄生虫接触史等。 5、转归不明确:行CT肺动脉造影并行肺动脉栓塞术,术后3小时咯血仍增多,继续微泵垂体后叶素等止血对症处理,住院16天出院。,二、诊断,本病初步诊断考虑: 一、支气管内膜结核; 二、左上肺纤维性肺结核; 三、肺大泡; 四、轻度失血性贫血; 五、慢性咽喉炎。,支持点: 1、本病主要临床表现为咯血伴低热; 2、有陈旧结核的影像表现; 3、CT提示肺部含气不全,考虑局部支气管有狭窄或阻塞; 4、出血后CT检查肺部未见异常,考虑出血点位于左上肺含气不全区; 5、再次肺动脉造影并肺动脉栓塞术后出血仍增多,考虑为支气管动脉引起的出血; 6、CT示两上肺、右下肺背段胸膜下多发肺大泡形成 ; 7、患者咯血,血红蛋白108/L ; 8、喉镜检查:咽喉炎 。,鉴别诊断,1、支气管扩张(咯血常见,CT未提示可排除) 2、肺ca (支持点:慢性咯血史、刺激性咳嗽,CT未见明确占位,但细小病变如支气管内膜CA未能排除) 3、肺大泡破裂(多为胸腔内出血,CT未提示) 4、血液病(少见,血液及骨髓检查未完善,暂不支持) 5、肺寄生虫(未作粪便检查,CT未提示),11,6、上消化道出血(无消化道病史及体征,胃镜检查正常) 7、循环系统病变(无消化系统病史及体征,未完善相关检查) 8、免疫系统,系统性红斑狼疮(缺乏病史及体征,未作相关检查) 9、先天性疾病,肺AV瘘、肺A瘤(肺A造影不支持) 10、慢支肺气肿(无病史及体征),三、本病有何经验教训,1、放宽思维,要把少见病、罕见病考虑进去。 2、完善病史及相关检查,如循环系统、支气管动脉DSA、免疫系统、血液系统等。 3、可试行诊断性治疗以明确诊断,可使用抗结核药物。 4、在缺乏阳性体征时,要考虑执行相关辅助检查。,THANKS!,Click to edit title style,ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.,Title,Text in here,Text in here,Text in here,Text in here,Click to edit title style,Description of the contents,ThemeGallery is a Design Digital 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Description of the contents,ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.,2019/8/23,21,可编辑,Click to edit title style,2005,2006,2007,2007 statistics title,2007 statistics title,(unit : %),(unit : %),* 2007 Statistics agency statistics,* 2007 Statistics agency statistics,50%,2005,2006,2007,90%,15%,96%,35%,70%,Contents of the product, and please fill it out.,ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.,Click to edit title style,ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.,80%,50%,30%,20%,Title in here,Title in here,Title in here,Title in here,A,B,C,D,Description of the contents,ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.,Description of the contents,Description of the contents,Description of the contents,M1,M2,M4,M3,Click to edit title style,Click to edit title style,ThemeGallery is a Design Digital Content & Contents 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