丹尼斯克的介绍.ppt

丹尼斯克的介绍,内容,丹尼斯克公司的简介 丹尼斯克菌种业务 发酵剂 菌粉 终端产品 丹尼斯克在中国,丹尼斯克的简介,丹尼斯克是食品配料，酶和生物解决方案的世界领导者。 利用天然原材料，科学知识，为健康安全产品开发和提供生物配料。,格林斯德(丹尼斯克前身)成立于1924年 丹尼斯克集团组建于1989年 股票在哥本哈根交易所上市 雇员数：约6,853名 (2009/10) 销售收入：164亿人民币 /137亿丹麦克郎 (2009/10) 18.37亿欧元 全球性公司： 40个国家有80多个分公司 总部：丹麦哥本哈根,丹尼斯克简介,丹尼斯克简介,组织架构,丹尼斯克简介,24.6亿人民币,27.9亿人民币,2009/2010销售额 销售总额：164亿人民币,Vission-Mission-Strategy,Vission: To be the First chioce provider of bio-based ingredients to industry globally. 成为世界上生物源配料的第一供应商 Mission: To help our customers increase their competitiveness through innovative, sustainable and bio-based ingredient solutions that meet market demand for healthier and safer products.通过创新，可持续发展和生物源配料的解决方案提高我们客户的竞争力，满足市场对健康安全产品的需求。 Strategy：To create value through：organic and acquisitive growth by leveraging and strengthening our market access, applications and technology platforms ；talented and engaged people.利用和加强市场准入，应用和技术平台来创造有机增长；重视人才,丹尼斯克简介,年销售额的6.5%投入研发 2009/10年度投入10.6 人民币（销售总额164亿人民币） 1059名全职研发人员 （2009年10月） 拥有9300多份有效专利（2009年12月）,Innovation is key to Danisco,丹尼斯克简介,丹尼斯克的菌种业务,丹尼斯克菌种 : 在菌种方面有着100年的经验,1906 Marschall 的创立 (凝乳酶和菌种培养基) 1907 Visby 实验室的建立 1960 Lacto-Labo 的创立 (加速成熟的菌种) 1981 Eurozyme 的创立 (冷冻干燥的乳酸发酵菌种) 1983 罗纳普朗克并购 Lacto-Labo 1988 罗纳普朗克并购 Eurozyme 1990 罗纳普朗克并购 Marschall Texel 的创立 (合并 Lacto-Labo, Eurozyme 和Marschall), 并100%归属罗纳普朗克 1998 Texel 改为罗地亚食品部门 丹尼斯克收购 Visby (冷冻和冻干菌种) 2004 丹尼斯克收购罗地亚食品并建立丹尼斯克菌种部门,目标 : 成为世界领先的应用于乳制品和健康食品工业的菌种供应商。,丹尼斯克菌种研发优势：三大技术支柱,主要方面,稳定性,满足客户目标产品的保质期要求,目标,功效性,通过独特的筛选流程和临床试验评估，开发并提供针对特别情况的益生菌菌株或菌株组合配方,应用技术,拓宽益生菌的应用领域,丹尼斯克菌种研发优势： 唯一自有营养健康中心的菌种供应商,丹尼斯克营养健康中心-位于芬兰,Developed own technology, human gut model, EnteroMix, to determine the mode of action and/or to benchmark functional ingredients 丹尼斯克独有的模拟人体胃肠道微生态条件，并可与体外发酵相结合以研究益生菌，益生原等原料的生理功能 . 在以下方面具有丰富经验 Intestinal microbiology 肠内微生态 Physiology 生理学 Immunology 免疫学 Biochemistry 生物化学 Biomathematics 生物数学 Scientists with over 150 publications 富有经验的科学家及150 多篇学术论文,丹尼斯克的菌种产品,丹尼斯克菌种产品,Cultures Dairy Yogurt and fresh fermented milks YO-MIX Yogurt Cultures Cheese CHOOZIT Cheese cultures FlavoGard Kefir-D Meat TEXEL Meat Cultures Protective Cultures HOLDBAC Protective Cultures Probiotics 终端产品,丹尼斯克的菌种产品 Cultures,丹尼斯克菌种产品YO-MIX Yogurt Cultures,丹尼斯克菌种产品 CHOOZIT Cheese cultures,丹尼斯克菌种产品 FlavoGard,成分：High aminopeptidase yielding strain of Lactococcus lactis subsp. Crem 应用： Hard and semi-hard type, in particular low fat cheese and aged Cheddar 功效： Bitterness prevention 抑制苦味 Texture improvement of low fat cheese 低脂奶酪质构改善,Kefir-D cultures,丹尼斯克菌种产品Kefir-D cultures,丹尼斯克菌种产品TEXEL Meat Cultures,一系列的直投式发酵剂，有助于肉制品色泽，质构和风味的形成和其中的微生物的质量。,丹尼斯克菌种产品 HOLDBAC Protective Cultures,丹尼斯克的菌种产品 Probiotics,丹尼斯克菌种产品FloraFIT Customizable Probiotics,FloraFIT Customizable Probiotics Versatility is the name of the game with FloraFIT probiotics. 多功能性 Our FloraFIT cultures are trusted by many of the worlds leading manufacturers of dietary supplements and nutritionals. 受到许多膳食补充剂和营养品领先生产商的信任 Its up to you to decide what you want us to provide - whether thats your own customized formulation or, if you prefer to do your own blending, individual culture concentrates. 选择自己定制配方或是单个菌株 Using FloraFIT, your final products will not only meet the specific needs of your customers, they will quite simply be one of a kind. 不仅满足客户的特定需求，也会将是独一无二的产品,FloraFIT single strains,最新发表的BI07对过敏性皮炎（AD）的抑制,Internatioanal Jounal of Probiotics and Prebotics. Vol.5.No.2.pp.53-60,2010 Probiotics to young children with atopic dermatitis: a randomized placebo-controlled trial R Gobel, N Larsen, C Molgaard, M Jakobsen and KF Michaelsen,University of Copenhagen, Denmark 丹麦哥本哈根大学 Purpose: Evaluate the clinical and immunological changes of AD after consumption of Daniscos probiotic strains Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07. 目的：评估服用丹尼斯克NCFM和Bi-07后,异位性皮炎（湿疹） 的临床和免疫学上的变化。,最新发表的BI07对过敏性皮炎（AD）的抑制,The study involved a double blind, randomized, placebo-controlled intervention in which fifty children with AD, aged 7-24 months, were given supplements containing either Daniscos L. acidophilus NCFM (1010 CFU/day), B. lactis Bi-07 (1010 CFU/day) or a placebo for 8 weeks. 双盲，随机，安慰剂对照。 50个婴儿，7-24个月大。 分别服用丹尼斯NCFM(1010 CFU/day)，Bi-07(1010 CFU/day) 8个月 Results showed a significant reduction in severity of AD in the Bi-07 group, together with an improved ratio of IFN- and IL-10. The possibility of beneficial immunological effects of this B. lactis Bi-07 probiotic strain in young children could be of great interest. 乳双歧杆菌Bi-07能明显缓解婴幼儿异位性皮炎(湿疹)症状，食用后体内免疫相关细胞 因子IL-10(人白细胞介素10)和IFN-(干扰素-)等的比率也显著增加，并且没有副作用。,FloraFIT customers products,Metabolic Health Labs Daily PRObiotic Available in North America,This product and these statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.,The most important benefits Daily PRObiotic product offers are: Assisting in the critical synthesis of vitamins and the absorption of nutrients from our food intake 有助于维生素的合成，营养的吸收 Protection against infections as it is harder for harmful bacteria and other pathogens to inhabit the host 保护免受感染 The stimulation of the bodys own natural immune defense as the gut is the center of the bodys immunity 刺激人体先天性免疫系统 By helping to promote regularity, they help the body rid itself of toxins 清理毒素 Prevention of an overgrowth of bad bacteria in the vaginal flora, protecting against vaginosis and yeast infections 抑制阴道中有害菌的过度繁殖,FloraFIT customers products,Metabolic Health Labs Daily PRObiotic Available in North America,FloraFIT customers products,Healthy Origins Probiotic 30 Billion CFUs Available in USA & Canada,Other Ingredients Vegetable Capsule (Cellulose, water), Microcrystalline Cellulose, Vegetable Magnesium Stearate, silicon Dioxide. No Sugar, Salt, Yeast, Wheat, Starch, Corn, Fish, Shellfish, Nuts, Tree Nuts, or Egg. Contains minimal residual amounts of dairy, soy, and gluten, peptides which are used in the fermentation process.,FloraFIT customers products,Healthy Origins Probiotic 30 Billion CFUs Available in USA & Canada,Description 100% Natural 纯天然 Supports a healthy digestive and immune system 维护肠道健康和免疫能力 8 strains and 30 billion colony forming units 8种菌株，300亿cfu Stomach acid resistant 耐胃酸 A dietary supplement Florafit Suggested Use As a dietary supplement, take one Vcap once or twice daily with or before meals.,Howaru品牌下既有单一菌株也有针对不同情况的菌株组合,Gut health,Immune modulation,丹尼斯克菌种产品HOWARU Premium Probiotics,丹尼斯克菌种产品HOWARU Premium Probiotics,HOWARU single strains,丹尼斯克菌种产品HOWARU Premium Probiotics,HOWARU proprietary blends,丹尼斯克菌种产品HOWARU Dophilus,HOWARU Dophilus的健康声明： 维护健康的有益菌和有益微生态的平衡 增强有益的微生态 对胃肠道的病原菌有抑制作用，减少人体疾病发生的风险因子 支持健康的消化功能 辅助乳制品乳糖的吸收，预防乳糖不耐症,HOWARU Dophilus HOWARU 嗜酸乳杆菌NCFM,人体来源：1970s从人体粪便中分离得到。 “North Carolina Food Microbiology”, the research laboratory at North Carolina State University (NCSU) where this successful isolation took place. 在北美市场上应用超过30年，国际上使用超过15年 80篇文献 唯一全基因序列发表的嗜酸乳杆菌,ATCC：SD5221,Overview of Howaru Dophilus (NCFM) studies Howaru 嗜酸乳杆菌研究综述 (NCFM),Selection 选择,Safety 安全,Immune modulation Improved immune functions 免疫调节 增进免疫能力,Intestinal health Improved intestinal functionality 肠健康 改善肠功能,Identification (genome sequenced) 鉴定（基因组序）,In vivo animal trial 体外和动物试验,In vitro 体外试验,Human studies人体临床,Safely consumed for over 30 years 安全消费超过30年,No transferable antibiotic resistance 无可转换的抗生素耐受,Reduced colonic hyperplasia in mice 减少小鼠的小肠细菌增生,Enhances immune response in immune-deficient and pathogen-challenged mice 提高具有免疫缺陷和受到病菌感染的小鼠的免疫能力,Increases fecal levels of beneficial lactobacilli 增加人粪便中有益乳酸菌数量,Safe for human consumption 人类消费安全,Reduced risk for non-infectious diseases 减少非感染性疾病的风险,Reduced risk for infections 减少感染的风险,Prevention of intestinal Malfunctions 防止肠功能异常,Tolerance towards acid and bile 酸和胆汁耐受性,Adherence to intestinal epithelium 附着在肠上皮细胞,No translocation 无转移,Good technological properties 良好的技术属性,Reduction lmakers of colorectal cancer 降低大肠癌的发生率,Antagonises pathogens in mice 抗菌作用,Reduces Candida infections 减少念球菌的感染,Improves metabolic activity of intestinal microflora 改善肠道菌群的代谢作用,Reduces lactose intolerance symptoms 减轻乳糖不耐症,NCFM - 增加肠道有益菌数量,Ten human subjects participated in the study. There were ve males and ve females, ages 2047 years, including two vegetarians. 10人，5男5女，包括2名素食者 年龄：20-47 Three periods: An initial 2-week baseline period; 最初的2周的基线期 (2)The premix treatment period during which each subject consumes 1010 cells of L. acidophilus NCFM (a generous gift from Rhodia Inc., Madison, WI, USA) premixed with 240 ml skim milk; 2周的治疗期，服用加入了1010 cfu的L. acidophilus NCFM 240ml的脱脂牛奶。 (3) A 2-week washout period immediately after the premix treatment.2周的洗脱期 During each period, two to four faecal samples were collected and analysed.,SuI, et al. 2002. J. Appl. Microbiol. 93: 907-912.,NCFM - 增加肠道有益菌数量,Conclusions: The probiotic L. acidophilus NCFM can survive through the human GI tract, but cannot colonize itself during the two-week consumption. 能够在人体肠道中存活，但是并不能在两周的服用期间繁殖。,NCFM -降低肠道菌源酶的活性,Goldin et al. Am J Clin Nutr 1984; 39:756-761,Twenty-one subjects, 16 women and five men. The mean age for the men was 29.2 yr and for the women 27.9 yr with no subject older than 33 yr. 21人，16女（平均年龄27.9），5男（平均年龄29.2），没有一个人超过33岁。 Five experimental periods： 4wk of a control period; 4wk of plain milk feeding; 4 wk of control, without any dietary supplements; 4 wk of milk containing 2 x 106/ml viable L acidophilus NCFM（500ml/day）; 4 wk of control, without any supplements. Three bacterial enzymes were assayed: -glucuronidase, nitroreductase, and azoreductase . 葡糖苷酸酶，硝基还原酶和偶氮还原酶,NCFM -降低肠道菌源酶的活性,Reductions of 2- to 4-fold in the activities of the three fecal enzymes were observed only during the period of lactobacilli feeding. 只有在服用嗜酸乳杆菌期间，三种酶的活力下降了2-4倍。,NCFM - 改善乳糖吸收,未接种的牛奶 添加NCFM的牛奶,摄入NCFM后,症状改善,Montes, et al. 1995. J Dairy Sci 78:1657-1664,腹痛, 腹胀, 腹气, 痉挛, 肠胃胀气, 腹部发出隆隆声的组合症状,结果,Twenty children (9 boys and 11 girls, ages 5 to 16 yr), who were documented to hve lactose malgigestion,HOWARU customers products,Poland OSM Pitnica,HOWARU Dophilus (Lactobacillus acidophilus NCFM),HOWARU customers products,USA Yocream High Culture Frozen Yogurt with HOWARU Dophilus Premium Probiotics,1 billion L. acidophilus NCFM probiotics bacteria per serving 1109 L. acidophilus NCFM Supports good digestive health 维持良好的消化 Improves intestinal microbial balance 增进肠道菌群平衡 Aids in the digestion of dairy products 有助于增进日常消化 Inhibits harmful bacteria and promotes improved digestion 抑制有害菌,HOWARU customers products,USA Attune Attune wellness bar with HOWARU probiotics,The probiotics in Attune have been clinically tested to support a healthy digestive system and a strong immune system. 肠道健康，增强免疫能力 Attune wellness bars also include prebiotics, which support healthy digestive function and work in harmony with probiotics. 益生元 These include Lactobacillus acidophilus NCFM, Lactobacillus casei Lc-11 and Bifidobacterium lactis HN019.,HOWARU customers products,BioNeed Nutritionals Corp BIO-260 Available in Taiwan,HOWARU Bifido的健康声明： 促进肠道蠕动，胃肠道的运载功能 改善肠道舒适性（疼痛，胀气，便秘） 帮助/维护/补充肠道微生态 增强有益的，健康的微生态 支持食物消化功能,丹尼斯克菌种产品HOWARU Bifido,HOWARU Bifido HOWARU 乳双歧HN019,A fruit of a five-year research project conducted by the New Zealand Milk and Health Research Centre, the New Zealand Dairy Research Institute and other internationally renowned health researchers. Bifidobacterium lactis HN019,originating from dairy. 来源于乳制品 The scientific name of the strain is Bifidobacterium animalis subsp. Lactis subsp.nov.HN019,Selection 选择,Safety 安全,Immune modulation Improved immune functions 免疫调节 增进免疫能力,Intestinal health Improved intestinal functionality 肠健康 改善肠功能,Identification 鉴定,In vivo animal trial 体外和动物试验,In vitro 体外试验,Human studies人体临床,No acute oral toxicity 无急性口服毒性,No transferable antibiotic resistance 无可转换的抗生素耐受,Increased resistance to infection 增强感染抵抗力,Improved natural immune response 增强先天性免疫能力,Improved microecology of the gut ,increase in lactobacilli & bifidobacteria levels 改善肠道微生态，提高乳酸菌和双歧杆菌的数量,Safe for human consumption 人类消费安全,Reduced risk for non-infectious diseases 减少非感染性疾病的风险,Reduced risk for infections 减少感染的风险,Prevention of intestinal Malfunctions 防止肠功能异常,Tolerance towards acid and bile 酸和胆汁耐受性,Adherence to intestinal epithelium 附着在肠上皮细胞,No translocation 无转移,No degradation of gastric mucin 对肠粘膜无降解,Improved acquired immunity antibody response 增强获得性免疫能力,Improved natural immune response. Natural killer cell activity-phagocytosis 增强先天性免疫能力。NK细胞的杀菌作用,Overview of Howaru Bifido (HN019) studies Howaru 乳双歧研究综述 (HN019),Bifidobacterium lactis HN019 提高非特异性免疫能力,目的：为了验证口服普通的低脂牛奶和乳糖水解后的低脂牛奶中的HN019提高非特异性免疫能力作用。 设计：三个阶段，前期干预，为期九个星期。 组织者：台北医学院附属医院 对象：50名台湾人（41-81岁，平均年龄60） Interventions: Stage 1 (run-in diet): 25g/200 mL reconstituted LFM powder, twice daily for 3 weeks. Stage 2 (probiotic intervention): LFM（Group A: n=27） or LFM-LH（Group B: n=23）, supplemented with 109 CFUs/g L. rhamnosus HN001 in each case, for 3 weeks. Stage 3 (wash-out): LFM for 3 weeks. 检测结果：体外中性粒细胞的吞噬作用；天然杀伤细胞的肿瘤破坏作用。,Chiang et al. Eur. J. Clin. Nutr. 2000, 54:849-855.,Bifidobacterium lactis HN019 提高非特异性免疫能力,PMN cell phagocytosis,NK cell tumour killing activity,Bifidobacterium lactis HN019 改善粪便中双歧杆菌和乳酸杆菌的数量,HOWARU Bifido,Gopal,et al 2003. Nutr. Res. 23:1313-1328.,Bifidobacterium lactis HN019 对健康成年人肠道运载时间的影响,三组，安慰剂对照双盲临床实验，目的是评价两种剂量的双歧杆菌HN019对肠道运载时间和健康成年人消化状况的影响 地点：美国德克萨斯州 100个位胃肠道症状的受试者（平均44岁，64%的女性，60%的黑人）随机分成三组，一组每天摄入1010CFU的HN019（高剂量；n=34），一组摄入109CFU（低剂量；n=34），和安慰剂组（n=33），为期44天。 肠道运载时间由第0.14天的X射线测得（摄的胶囊中含有放射性标志物） 进食频率和种类由受试者日志进行评估 消化道症状频率（打嗝，恶心，腹泻，胀气，便秘，反胃，腹痛，和不规律排便）在使用补充剂前后记录下来。,在运转周期试验中，健康成年人摄入14天 HN019后的变化,Bifidobacterium lactis HN019 对健康成年人肠道运载时间的影响,平均肠道运载时间在高剂量（从4930降低到2132小时，p0.001）和低剂量组 （6033至4139小时，p=0.01）降低，但是安慰剂组（4331至4433小时）不变。,在14天摄入HN019补充剂后，有严重胃肠道疾病人群症状的变化,在记录下来的9种消化道症状中，高剂量改善了8种症状，低剂量组改善了7种，而安慰剂组仅改善了2种症状。,Bifidobacterium lactis HN019 对健康成年人肠道运载时间的影响,HOWARU customers products,Poland Bakoma BACTIV,HOWARU Bifido,HOWARU customers products,Metabolic Maintenance Probiotic Immune with HOWARU Available in USA,Enhancing immune function without an increased risk of an inflammatory response.,HOWARU customers products,XYMOGEN ProbioMax DF Available in USA & Canada,HOWARU Rhamnosus HOWARU 鼠李糖HN001,New Zealand Dairy Research Institute, Originally isolated from a cheddar cheese produced in New Zealand and has been consumed as part of dairy products for more than 20 years. 切达干酪，20多年 The studies revealed that Rhamnosus HN001 satisfies the most stringent requiements for probiotic properties.Great attention was paid to the strains immune-enhancing properties, which have been documented in several studies. Australian Government Analytical Laboratories (AGAL) deposit number NM97/09514,Safety 安全,Selection 选择,Safety 安全,Immune modulation Improved immune functions 免疫调节 增进免疫能力,Intestinal health Improved intestinal functionality 肠健康 改善肠功能,Identification 鉴定,In vivo animal trial 体外和动物试验,In vitro 体外试验,Human studies人体临床,No acute oral toxicity 无急性口服毒性,No transferable antibiotic resistance 无可转换的抗生素耐受,Increased resistance to infection 增强感染抵抗力,Improved natural immune response 增强先天性免疫能力,Improved microecology of the gut ,increase in lactobacilli & bifidobacteria levels 改善肠道微生态，提高乳酸菌和双歧杆菌的数量,Tolerance towards acid and bile 酸和胆汁耐受性,Adherence to intestinal epithelium 附着在肠上皮细胞,No translocation 无转移,No degradation of gastric mucin 对肠粘膜无降解,Improved acquired immunity antibody response 增强获得性免疫能力,Improved natural immune response. Natural killer cell activity-phagocytosis 增强先天性免疫能力。NK细胞的杀菌作用,Good technological properties 良好的技术属性,No risk of auto-immune diseases,No risk of platelet aggregation,Reduced incidence & severity of atopic eczema 降低湿疹的发生率和严重度,No adverse side effects in numerous human studies, including infants 在许多临床研究中对人体无副作用，包括婴儿。,Overview of Howaru Rhamnosus(HN001) studies Howaru 鼠李糖研究综述 (HN001),Lactobacillus rhamnosus HN001 提高人体先天性免疫能力,目的：为了验证口服普通的低脂牛奶和乳糖水解后的低脂牛奶中的HN001对天然免疫细胞的作用。 设计：三个阶段，前期干预，为期九个星期。 组织者：台北医学院附属医院 对象：52名中年到老年的志愿者（17名男性，35名女性，平均年龄63.5，44-80岁） Interventions: Stage 1 (run-in diet): 25g/200 mL reconstituted LFM powder, twice daily for 3 weeks. Stage 2 (probiotic intervention): LFM（Group A: n=25） or LFM-LH（Group B: n=27）, supplemented with 109 CFUs/g L. rhamnosus HN001 in each case, for 3 weeks. Stage 3 (wash-out): LFM for 3 weeks. 检测结果：体外中性粒细胞的吞噬作用；天然杀伤细胞的肿瘤破坏作用。,服用HN001后，两组的PMN的吞噬作用增加了19%和15%，天然杀伤白细胞的肿瘤破坏活性提高了71%和147%。,Lactobacillus rhamnosus HN001 提高人体先天性免疫能力,Lactobacillus rhamnosus HN001 对AD的作用,Objective: To determine whether probiotic supplementation in early life could prevent development of eczema and atopy at 2 years. 确定是否在生命早期补充益生菌能够防止两年后的湿疹的发生。 方法：双盲，随机，安慰剂对照。 孕妇随机服用，从怀孕35周到产后六个月。母乳喂养婴儿。她们的婴儿继续服用，从 出生到两岁大。 There were 2 treatment groups who received either L rhamnosus HN001 (6109cfu /d; n=157) or B animalis subsp lactis HN019 (9109 cfu /d; n=158), placebo (n=159) Eczema prevalence from birth to 2 years was dened using the UK Working Partys Diagnostic Criteria for atopic dermatitis modied for use in infants. Eczema severity from birth to 2 years was assessed by using SCORing Atopic Dermatitis (SCORAD) in all children regardless of their eczema diagnosis (as dened). SCORAD was analyzed dichotomously using a cutoff10 to exclude those with trivial rash. All staff were trained to apply SCORAD in a standardized way.,Lactobacillus rhamnosus HN001 对AD的作用,Results: Infants receiving L rhamnosus HN001 had a signicantly reduced risk of developing eczema by 2 years (14.8%) compared with infants in the placebo group (26.8%; Table II; Fig 2). The risk of developing SCORAD10 was signicantly reduced by 2 years in the L rhamnosus HN001 group (Table II; Fig 3). In contrast, there was no effect of B animalis subsp lactis HN019 on eczema prevalence or SCORAD10 by 2 years (Table II; Figs 2 and 3).,Lactobacillu