科技论文的撰写和发表.ppt

科技论文的撰写和发表,医学神经生物学国家重点实验室神经生物学系54237522治道楼909、911lanma,马兰,预告,鲁白教授：Howtopublishyourpapersinthetopscientificjournals本周三下午2点（306教室）秦伯益院士：（谈科研创新问题）10月10日（星期四）下午2点（306教室）,Why?为什么要撰写和发表论文？What?什么是科学研究论文？定义特点结构How?如何撰写科研论文？,Why?为什么要撰写和发表科研论文？,基础研究的成果以论文形式表现发表论文的质量与数量是衡量科研工作者水平和效率的客观标准PublishorPerish!,Why?为什么要撰写和发表科研论文？,研究结果只有发表了，他人才能重复、验证，结果才可能成为知识撰写和发表论文是科研工作的最后一道工序科学研究的目的是发表,Why?为什么要撰写和发表科研论文？,科学研究的关键是可重复性、可被他人验证科研工作者必须提供书面材料让同行知道他做了什么、为什么这样做、怎样做的、发现了什么？科研工作者不仅要“做”研究，而且要“写”研究,Why?为什么要开设科研论文构思、撰写和发表课程？,博士应具有构思、撰写和发表论文的能力研究生院要求博士研究生发表SCI论文研究生及部分导师缺乏科学交流技巧、“写”科学的训练,因此增加了博士论文的工作难度、影响了研究生培养的质量,课程的目的,知道Whatisagoodpaper掌握构思要点、基本撰写方法和技巧提高分析和表达结果的能力避免常见错误提高论文的可读性了解论文的投稿、评阅和发表过程增加论文被高影响力刊物接受的机率,主要内容,创新性选题撰写要点结果的表达投稿和评阅常见错误,口头报告实验记录学位论文综述基金申请学术道德,What?什么是科学论文？,公开发表的、描述新研究结果的书面报告；必须按一定的方式撰写和发表首次出版：新研究结果的首次公布以同行能够重复实验、验证结论的形式发表发表在同行很容易得到的刊物上或其它媒介（同行评议杂志）上,科研论文写作的要求,条理清楚，摆事实、讲道理语言简单、平实、明确、直接容易被理解和接受正确、准确地使用英语vetral/ventricle;casual/causal用最少、最短的词,科学论文的基本结构,Introduction,Methods,Results,andDiscussion(IMRAD)I:Whatandwhy?研究什么问题？为什么研究这个问题？M：How?如何研究的？R：What?发现了什么？D：What?发现意味着什么？,标题,重要性体现创新点包含所有关键词（检索）吸引人用动词、句子,采用动词（1）,Hippocampallong-termpotentiationisreducedbychronicopiatetreatmentandcanberestoredbyre-exposuretoopiates.J.Neurosci.HeterologousactivationofproteinkinaseCstimulatesphosphorylationofd-opioidreceptoratserine344andthisresultsinb-arrestin-andclathrin-mediatedreceptorinternalization.JBiolChemAnti-HIVagenttrichosanthinenhancesthecapabilitiesofchemokinestostimulatechemotaxisandGproteinactivationandthisismediatedthroughinteractionoftrichosanthinandchemokinereceptor.JExpMed,采用动词（2）,Divalentcationsandligandsinduceconformationalchangesthatarehighlydivergentamongb1integrins.JBiolChemInhibitionofCamKIIinrathippocampusattenuatesmorphinetoleranceanddependence.MolPharmacol.ChemokinereceptorCCR5functionallycouplestoinhibitoryGproteinsandundergoesdesensitization.JCellBiochemCarboxylterminusofdeltaopioidreceptorisrequiredforagonist-dependentreceptorphosphorylation.BiochemBiophysResCommun,采用动词（3）,N-methyl-D-aspartateattenuatesopioidreceptor-mediatedGproteinactivationandthisprocessinvolvesproteinkinaseC.MolPharmacol.Endogenousdelta-opioidandORL1receptorscoupletophosphorylationandactivationofp38MAPKinNG108-15cellsandthisisregulatedbyproteinkinaseAandproteinkinaseC.JNeurochemActivationofN-methyl-D-aspartatereceptorattenuatesacuteresponsivenessofdelta-opioidreceptors.MolPharmacolCholecystokinin-Breceptorantagonistsattenuatemorphinedependenceandwithdrawalinrats.Neuroreport,采用词组,IdentificationofGprotein-coupledreceptorkinase2phosphorylationsitesresponsibleforagonist-stimulateddelta-opioidreceptorphosphorylation.MolPharmacolDifferentialrolesofcorticotropin-releasingfactorreceptorsubtypes1and2inopiatewithdrawalandinrelapsetoopiatedependence.Identificationofahumanbrain-specificisoformofmammalianSTE20-likekinase3thatisregulatedbycAMP-dependentproteinkinase.JBiolChemSelectiveinterferenceofb-arrestin1withkanddbutnotmopioidreceptor/Gproteincoupling.JBiolChem.Differentialandtissue-spesificexpressionofmitochondrialelongationfactorTuandTsduringdevelopment.ActaBiochBiophSinDifferentialefficaciesofkagoniststoinducehomologousdesensitizationofkopioidreceptor.NeurosciLett,采用词组（冒号）,Reactivationofmorphineconditionedplacepreferencebydrugpriming:roleofenvironmentalcuesandsensitization.PsychopharmacologyFive-transmembranedomainstructureissufficientforaGproteincoupledreceptor:Functionalfive-transmembranedomainchemokinereceptors.ProcNatlAcadSciUSA.EtorphineinhibitscellgrowthandinducesapoptosisinSK-N-SHcells:involvementofpertussistoxin-sensitiveGproteins.NeurosciResRetardationofpaindevelopment:acaseofrecoveryfromcongenitalinsensitivitytopain.ActaAnaesthesiolScand,类似的研究（1）,Differentialregulationofbeta-arrestin1andbeta-arrestin2geneexpressioninratbrainbymorphine.NeuroscienceAcuteandchronicmorphinetreatmentsandmorphinewithdrawaldifferentiallyregulateGRK2andGRK5geneexpressioninratbrain.Neuropharmacology,类似的研究（2）,Directanddifferentialinteractionofbeta-arrestinswiththeintracellulardomainsofdifferentopioidreceptors.MolPharmacolDirectbindingofbeta-arrestinstotwodistinctintracellulardomainsofthedeltaopioidreceptor.JNeurochem,类似的研究（3）,Functionalexpression,activationanddesensitizationofopioidreceptor-likereceptorORL1inneuroblastomaxgliomaNG108-15hybridcells.FEBSLettEndogenousopioidreceptor-likereceptorinhumanneuroblastomaSK-N-SHcells:activationofinhibitoryG-proteinandhomologousdesensitization.Neuroreport,Notsogood(1),Mechanisticstudiesofthetranslationalelongationcycleinmammalianmitochondria.BiochimBiophysActaMolecularcharacterizationandfunctionalexpressionofopioidreceptor-likereceptor.CellRes.Functionalexpressionofopioidreceptor-likereceptoranditsendogenousspecificagonistnociceptin/orphaninFQduringembryogenesis.CellRes,Notsogood(2),Identificationandcharacterizationoflarge,complexformsofchloroplasttranslationalinitiationfactor2fromEuglenagr