帝斯曼公司介绍

0,DSM 帝斯曼化学The Innovator in the Industry化学工业的创新者,1,Introduction of Dr. Arnold Gloor (Switzerland ) 介绍阿诺.阁老 (瑞士),Master of Chemistry of Federal Technical University瑞士联邦工业大学的硕士研究生1993 F.Hoffman-La Roche AG, Pharma div. R&D 工作于霍夫曼罗氏公司, 原料药研发部1996 F.Hoffman-La Roche AG, Vitamin div. R&D 工作于霍夫曼罗氏公司, 维生素研发部2003 DSM acquisition of Vitamin Div, Marketing dept. Starting Aroma chemical business. DSM购并了维他命部门, 工作于市场部, 开始从事合成香料销售业务.,2,Globally active multi-specialty chemical company活跃于全球的”多面性专用化学品”化工公司Global leadership(75% of product portfolio) 占全球的领导位 (约75%的产品为专用化学品)Innovation driven 以产品创新驱动,Key data 20062006年的公司数据Sales : 8352 million销售额: 83.52亿欧元EBITDA: 808 million税前利润: 8.08亿欧元Employees 22000雇员人数: 约2.2万人Locations: 250 (5 continents)公司地点: 约250处(分布于5大洲)Investments: 500 mio 投资总额: 约5亿欧元 Trademarks: 13000注册商标数: 1.3万个Patent Estate: 36000注册专利数: 约3.6万个R&D spend: 300 Mio 研发费用额: 约3亿欧元,Performance Materials,DSM in 2006帝斯曼2006年数据,Nutrition营养产品 24 亿,PerformanceMaterials功能性产品 27 亿,IndustrialChemicals工业化学品 19亿,Pharma原料药 9 亿,Other其它 4 亿,3,Competences,mechanical engineering,chemical engineering,chemistry,polymer technology,material science,adv. organic chemistry,biotechnology,Evolution公司进展,Coal,Fertilizers,Petro-chemicals,PerformanceMaterials,Life Science Products,Customer intimacy以客户为导向,BioterialsBiologics,1902 1930 1950 1970 1990 2000 2010,DSM: a Century of Transformation 帝斯曼: 一个世纪的演进史,机械工程,化学品,化学工程,聚合物,材料科学,尖端有机化学,生物技术,煤碳,化肥,石油化工,功能性材料,生命科学产品,生物制剂,4,Key end-use markets主要针对的最终市场,Human Nutrition and Health人类营养及健康,Pharmaceuticals原料药,Agriculture农业,Textiles纺织品,Animal Nutrition and Health动物营养及健康,Building and construction建筑和建造业,Automotive and Transport汽车和运输业,Electrics and Electronics电子及电器业,Metal and Machine building金属及机械建造,Aroma chemicals合成香料,5,DSM Organizational Chart帝斯曼的组织架构,Industrial Chemicals工业化学品,Performance Materials功能性材料,Pharma 原料药,Nutrition 营养,DSM Managing Board董事会,DSM Innovation Center创新开发中心,Corporate Staff全体员工,Shared Competences& Business Support公共职能部及商务支持,DSM Nutritional ProductsAnimal Nutrition and Health动物营养和健康Human Nutrition and Health 人类营养和健康New Business Development 新业务开发Aromachemicals 合成香料,DSM Food Specialties 食品专有原料,DSM Pharmaceutical Products 原料药产品,DSM Anti-Infectives 抗感染药,DSM Resins 树脂Composite Resins复合树脂Coating Resins 涂料树脂Desotech 光纤着色涂料NeoResins 新型树脂,DSM Engineering Plastics 工程塑料- DSM Dyneema 高强纤维,DSM Elastomers 合成橡胶,DSM Agro 农药,DSM Melamine 蜜胺,DSM Fibre Intermediates 纤维中间体,6,DSM Key Figures 帝斯曼的一些重要指标,* excluding exceptional items* 去除例外项目,7,DSM Nutrition Cluster帝斯曼营养产品 产品分布,End Markets: 最终市场 Food 食品 Feed 饲料 Dietary & Health Supplements 减肥及健康食品 Cosmetics 化妆品 Fragrance & Intermediates 香料及中间体,Total Market Size: 38 bln3-4% Annual Growth总的市场规模: 380亿欧元每年3-4的增长,AnimalNutrition & Health动物营养及健康,Human Nutrition &Health人类营养及健康,Personal Care 个人护理,其它Other,Food Specialties 食品专用化学品,Fragrance & Intermediates香料及中间体,8,DSM Nutritional Products帝斯曼营养产品,Largest Vitamin and Carotenoid producer in the world世界上最大的维生素和类胡罗卜素的生产商Producing Vitamins since 1933从1933年开始生产维生素Producing Aroma Chemicals since 1964从1964年开始生产合成香料Large Scale Production产量巨大,9,DSM Nutritional Products 帝斯曼营养产品Global network of dedicated plants 全球生产自有基地网络,Manufacturing Sites,Belvidere,Arachidonic acid,Freeport,-Carotene,Dalry,Vit C Calpan Octabase,Village-Neuf,Canthaxanthin Apoester Apocarotenal Lycopene Biotin,Grenzach,Vit B1, B2, B6, D3 Biotin Intermediates,Lalden,Aromachemicals Intermediates for Vit A, E,Tienen,Citric acid,Sisseln,Vit A, E, K1 Folic acid Astaxanthin Aromachemicals Intermediates,Xinghuo, Gonglu, Wuxi,Vit B6, A Teavigo Citric acid, -胡罗卜素,花生四烯酸,柠檬酸,维生素C卡尔班辛烷基,维生素A,E,K叶酸虾青素合成香料中间体,维生素A,B6茶维力柠檬酸,维生素B1,2,6,D3维生素H中间体,角黄素阿朴酯阿朴胡萝卜素醛蕃茄红色素维生素H,合成香料维生素A,E的中间体,10,Aroma Chemicals合成香料产品,LINALOOL FAMILY 芳樟醇家族LINALOOL 芳樟醇LINALYL ACETATE 乙酸芳樟酯TETRAHYDROLINALOOL 四氢芳樟醇TETRAHYDROLINALYL ACETATE 乙酸四氢芳樟酯ETHYLLINALOOL 乙基芳樟醇ETHYLLINALYL ACETATE 乙酸乙基芳樟酯,IONONES 紫罗兰酮BETA- IONONE 乙位紫罗兰酮ISONALINE (Methyl-Ionone) 异甲基紫罗兰酮,BENZOIDS 苯甲醛下游CINNAMIC ALDEHYDE 苯甲醛CINNAMIC ALCOHOL 桂醛BENZYL ALCOHOL 苯甲醇PHENYLPROPANOL 苯丙醇,SPECIALITIES 小原料NEROLIDOL 橙花叔醇GERANYL ACETONE 香叶基丙酮METHYLHEPTENONE 甲基庚烯桐ISOPHYTOL 异植物醇,11,When it started 起源Hydro Power 水能,12,Cheap Electricity廉价的电能,Grande Dixence, Switzerland,When it started 起源Electricity 电能,Lonza AG 龙沙化学 1897 Acetylene from Ca-Carbide Diketene, Ammonia从电石制乙炔. 双烯酮, 氨水Aluminium Industrie AG 铝业公司 1905 Refining 提炼CIBA AG 汽巴精化 1898 Electrochemistry, Indigo 电化学英迪格Electric Rail Network 电器铁路网1890,Courtesy Lonza AG,Courtesy ABB Ltd,13,At the beginning of the 20th century, the perfume industry needed cheap aromachemicals for the growing demand.20世纪初, 香料工业开始需要大量廉价的合成原料来应对日益增长的需求.Natural sources were too expensive. 天然来源的香料十分昂贵.A lot of research started to develop chemical processes for the manufacturing of aromachemicals based on naphta.许多针对以液化石油汽为基础的化学合成香原料研究开始进行.1919 the synthesis of Linalool based on Acetylene was discovered and later industrialized.1919年, 以乙炔为起始原料的芳樟醇被开发出来, 随后工业化成功.Today Linalool is still produced according the same principles.Later, the access to other aromachemicals was developed based on Acetylene今天,芳樟醇还是用同样的工艺生产, 后续, 以乙炔为起始原料的其它香原料陆续出现.,14,When it started 起源:Synthesis of Aromachemicals 合成香料,Prof. Leopold Ruzicka and students1937, ETH Zurich, Switzerlandon the right side: Dr. Tadeus Reichenstein(courtesy Library ETHZ)卢兹卡教授和他的学生, 1937年摄于瑞士苏黎士. 最右边是塔杜.雷切斯坦博士,15,When it started 起源First Linalool Synthesis 芳樟醇最早的合成路线,L. Ruzicka and V. Fornasier, 1919,甲基庚烯酮,去氢芳樟醇,芳樟醇,L. 卢兹卡和V.富纳什, 1919年的合成路线,16,When it started 起源:Ruzicka fundamental research 卢兹卡的基础研究,Important Research Topics研究的里程碑:1916 Fenchone 葑酮1919 Linalool, Beta-Collidine 芳樟醇, 乙位-三甲基吡啶1921 Nerolidol, Farnesol, Irone 叔花叔醇, 金合欢醇, 鸢尾酮 Musk, Civetone, Muscone 麝香, 灵猫酮, 麝香酮1930 Male Sex Hormones 雄性荷尔蒙1937 Triterpenes, Steroids 三萜烯, 类固醇 Industrial Collaborations 工业上的合作者Haarmann & Reimer 哈默及雷默Chuit, Naef &Firmenich 徐特,纳夫及芬美意Ciba 汽巴精化Rockefeller Foundation 勒克菲勒基金,courtesy Library ETHZ,17,METHYLHEPTENONE 甲基庚烯酮Dehydrolinalool去氢芳樟醇,LINALYL ACETATETH-LINALYL ACETATE乙酸芳樟酯, 乙酸四氢芳樟酯,LINALOOL,GERANYLACETONENEROLIDOL香叶基丙酮, 橙花叔醇,DIHYDROLINALOOLTETRAHYDROLINALOOL二氢芳樟醇, 四氢芳樟醇,When it started 起源:Synthesis of Aromachemicals 合成香料,Linalool 芳樟醇:Ruzicka 卢兹卡, 1919, Dehydrolinalool 去氢芳樟醇Nerolidol 橙花叔醇:Ruzicka 卢兹卡, 1923, Geranyl Acetone 香叶基丙酮Geranylacetone 香叶基丙酮Caroll 卡罗, 1940, Linalool 芳樟醇Kimel 基米, 1943, Linalool 芳樟醇Saucy 绍西, 1960 70 Linalool 芳樟醇 70Linalyl acetate 乙酸芳樟醇Roche Development 由罗氏开发,18,Aside of the development in aromachemicals, Vitamins were discovered and identified.除了合成香料的发展以外, 维生素也被发现并鉴定出来.The biological effects of Vitamins were studied.对维生素进行了生物学研究.Main inventors were 主要的发明者是 Paul Karrer, Switzerland 保罗 卡瑞, 瑞士 Richard Kuhn, Germany 里查德 奎恩, 德国F. Hoffmann La Roche started to develop the first chemical synthesis for Vitamin E and AF. 霍夫曼 罗氏公司开发了第一条维生素A和E的合成路线.The developments were lead by Otto Issler (F.Hoffmann-La Roche)开发由奥特 依斯乐领导(霍夫曼.曼氏公司)The chemical processes were developed based on Acetylene化学合成路线是以乙炔为起始原料.,19,Richard Kuhn里查德 奎恩,Paul Karrer保罗 卡瑞,Hans von Euler-Chelpin汉斯 冯 乌乐-切乐平,Hugo Theorel雨果 特瑞l,Otto Warburg奥特 沃伯格,Otto Isler 奥特 依斯乐Vitamin E 1940Vitamin A 1945F.Hoffmann - La Roche AGF. 霍夫曼-罗氏公司,When it started 起源:Structural Identification and Isolation of Vitamins结构式鉴定以及维生素分离,20,When it started 起源Ionone synthesis starting from Acetone and Acetylene紫罗兰酮的合成起源于乙炔,丙酮路线,METHYLHEPTENONE 甲基庚烯酮Dehydrolinalool去氢芳樟醇,PSEUDOIONONE假性紫罗兰酮,METHYL PSEUSOIONONE 甲基假性紫罗兰酮METHYL GAMMA IONONE异甲基紫罗兰酮,BETA IONONE乙位紫罗兰酮维生素 A, Vit A,IONONES FOR CAROTENOIDS用于生产类胡罗卜素的紫罗兰酮,ISOPHYTOL异植物醇 维生素 E,Vit E,Vit A downstream intermediates维生素A的下游中间体 Lindlar 林德乐 1947 Beta-Ionone 乙位紫罗兰酮 Isler 依斯乐 1947, Pseudoionone 假性紫罗兰酮Pseudoionone 假性紫罗兰酮 Roche 罗氏 1967, (Kimel 基米 1943) Saucy 绍西 Marbet 马贝特 1971Methylpseudoionone 甲基假性紫罗兰酮 Saucy 绍西 Marbet 马贝特 1958 Dehydrolinalool去氢芳樟醇,21,The heads of Research of Givaudan and F. Hoffmann-la Roche decided to start a project to combine the chemical processes of Givaudan and F. Hoffmann la Roche.奇华顿和霍夫曼罗氏的开发的领导者决定把奇华顿和罗氏的化学品生产合并在一起.Bost chemical concepts are based on Acetylene and Deyhdrolinalool as key compounds.所有的生产都是以乙炔为起始原料的, 去氢芳樟醇是一个关键的中间体.Joint large scale manufacturing of aromachemicals and vitamins generated the best cost position.把产能可观的合成香料和维他命合并起来, 形成了成本上的巨大优势.,22,Modern Manufaturing Concept 现代的生产理念Terpene Tree - Fragrance and Intermediates for Vitamins萜类产品树 香原料和维生素中间体,METHYLHEPTENONE 甲基庚烯酮Dehydrolinalool去氢芳樟醇,LINALYL ACETATE 乙酸芳樟醇TH-LINALYL ACETATE乙酸四氢芳樟酯,PSEUDOIONONE假性紫罗兰酮,LINALOOL芳樟醇,GERANYLACETONE 香叶基丙酮NEROLIDOL 橙花叔醇,DIHYDROLINALOOL去氢芳樟醇TETRAHYDROLINALOOL四氢芳樟醇,METHYL PSEUSOIONONE 甲基假性紫罗兰酮METHYL GAMMA IONONE异甲基紫罗兰酮,BETA IONONE乙位紫罗兰酮,IONONES FOR CAROTENOIDS用于类固醇生产的紫罗兰酮,HEXAHYDROPSEUDOIONONE六氢假性紫罗兰酮 ISOPHYTOL异植物醇,23,Modern Manufacturing Concept 现代生产理念Hoffmann - La Roche set up 霍夫曼罗氏的建立,1964 Acquisition of Givaudan by F. Hoffmann La Roche AG 奇华顿被罗氏所收购1965 Foundation of Roche Teranol AG (since 2003 DSM Lalden) and site Sisseln 罗氏特兰公司成立(雷登基地. 被帝斯曼2003购并), 以及士森恩生产基地1966 Start up of Naphta Cracker 液化石油汽裂解装置建立,F. Hoffmann - La Roche AG霍夫曼.罗氏公司,24,Modern Manufacturing Concept 现代生产理念Spin Offs Acquisitions 分拆与购并,1964 Acquisition of Givaudan by F. Hoffmann La Roche AG 奇华顿被霍夫曼罗氏公司所购并1965 Foundation of Roche plant in Lalden (since 2003 DSM Lalden) 罗氏的雷登生产基地落成(2003年被帝斯曼所购并)1966 Start up of Naphta Cracker 开始液体石油汽裂解2000 Spin off Givaudan and 2003 Acquisition of Roche Vitmamins by DSM 奇华顿被分拆出来独立, 2003年帝斯曼购并了罗氏的维他命部门,DSM Site Lalden帝斯曼的雷登基地,Givaudan S.A.奇华顿,Flavour & Fragrance 香精香料,DSM SiteSisseln 帝斯曼的士森恩基地,Pharma 原料药,Diagnostic 诊断,DSM 帝斯曼,Roche 罗氏,F&F Industry 香精香料工业,Aroma chemicals合成香料,25,Intermediate Plant DSM Lalden, Switzerland 帝斯曼在瑞士雷登的中间体工