危险性分析的原则及其在食品安全中的应用.ppt

1,GeneralPrinciple欧洲污染水平/欧洲膳食结构,摄入量人群危险度(ng/人/天)(个肝癌/年/10万人)限量20g/kg190.0041(0.0006-0.01)限量10g/kg180.0039(0.0006-0.01)相差2个肝癌/年/亿人,30,例2.HBsAg()25%;中国污染水平/远东膳食结构,摄入量人群危险度(ng/人/天)(个肝癌/年/10万人)限量20g/kg1250.17(0.03-0.3)限量10g/kg1030.14(0.02-0.3)相差300个肝癌/年/亿人*1990-92年全国肝癌死亡率20/10万,31,CCFHACTIVITIES,32ndCCFH（1999）DecidedtoproceedinMRAonthebasisofpathogen/commoditycombinations；Elaboratedandagreedontentativeprioritylistofpathogen/commoditycombinations决定对病原食品组合进行微生物危险性评估，并提出暂定优先组合,32,CCFHDraftinggroups食品卫生法典委员会起草工作组,L.monocytogenesinready-to-eatfood(Germany)即食食品中的单增李斯特菌Salmonellaspp.inpoultry(Sweden)禽肉中的沙门氏菌Campylobacterspp.inpoultry(Netherlands)禽肉中的空肠弯曲菌Vibriospp.inseafood(UnitedStates)海产品中的副溶血性弧菌EnterohemorrhagicE.coliinmeat(UnitedStates)肉食品中的出血性大肠杆菌,33,WhyRAisneededinChina？我国为什么要进行危险性分析？,WTOCODEX/GBFOODINDUSTRYFOODSAFETYCONTROLGovernmentConsumersHEALTHPROTECTIONLifequalityknowledge,国际贸易食品法典/国家标准体系食品工业食品安全控制政府消费者保护消费者健康生活质量的提高对食品安全知识的需求,34,CaseinChinaTheControloftheDeterioratedSugarcaneFoodPoisoning,FreshsugarcanegrowninsouthernareaofChinaShipped,storedandsoldthroughthewinterseasoninthenorthernpartsofChinaContaminatedsugarcanecouldcausefatalfoodpoisoningwhensoldinthenextspring,35,Sugarcanepoisoning,ThefirstoutbreakofunknowncausessugarcanepoisoningoccurredinHenanProvincein1972From1972to1989:No.ofoutbreak:217No.ofcases:884No.ofdeaths:88Averagefatality:10%IdentifiedasaprioritytoassessandcontrolbyMOH,36,Etiologyandriskassessment,EtiologyandcausesstudywerebeencarriedoutbytheChineseAcademyofPreventiveMedicinein1980sArthriniumspp.wasthepathogenicfungus;3-nitropropionicacid(3-NPA)producedbyA.spp.wasprovedtobethecausativecompoundAssessmentwasmadeaccordingtocase-basedstudies,epidemiologicalandlaboratorystudies,37,Decisionmakingandmanagementactivities,Basedondiscoveryandassessment,MOHpromulgated:Diagnosticcriteriaandprinciplesforthemanagementofdeterioratedsugarcanepoisoning(WS/T10-1996);MethodsfortheisolationandidentificationofArthriniumstrainsandanalyzing3-nitropropionicacid(GB47689.16)MOHissuedanotificationonthepreventionandcontrolofDSPtoallprovincesofChinaAnationalhealthcampaignforpreventionandcontrolofthepoisoningwaslaunched,38,Goodresults,Asaresultoftheseefforts,sugarcanepoisoninghasbeensatisfactorycontrolledNotypicalcaseswerereportedinChinainthelast10years!,39,FAO/WHOActivatesinChina,WorkshoponMicrobiologicalRiskAssessmentSponsoredbyFAO/ILSI/WHO/MOH,May10-11,2002BeijingQuantitativeMicrobiologicalRiskAssessmentTrainingCourse(DavidVose)SponsoredbyWHO/INFS,May13-24,2002BeijingNationalWorkshoponIntroductiontoRiskAnalysisintheFisheryIndustrySponsoredbyFAO/INFOYU,Aug12-23,2002Shanghai,40,Riskanalysis-concludingsummary,RiskanalysisanditscomponentsProvideatoolformanaging