[生物医药论文精品a]具有多靶标作用gsk-3抑制剂的设计与活性研究

具有多靶标作用GSK3抑制剂的设计与活性研究A1A0A3A4A2A3A6A5A7A3A9A8A10A12A6A11A13A12A15A14A16A18A17A19A20A21A22A23A24A25A22A26A27A22A26A12A10A28A30430030A31A32A29A34A35A33A34A37A36A38A39A40A42A43A41A44A45GSK3A47A46A48A49A50A51A33A52A38A53,A55A54A56A51A57A58A59A60A61A37A36A62A63A64A50A51A57A53A33A65A66A67A68A69A70A71A72A73A74A75A76A77A78A79A76A77A80ADA79A81A82A83A84A85A86A87A88A89A90A91A77A92A93A79A81A94A95A96A97A98A99A100A101A71A72A79A102A103A104A105A106A107A108A109A92A93A79A104A105A110A111A106A112A113A69A70A79A114A112A82A107A108A109A92A115A79A71A72A116A117A83A104A118A119A69A70A79A114A112A82A120A121A122A123A124A125GSK3A126A127A128A129A100A101A130A117A79A131A132A76A77A83A115A133A134A119A81A94A135A96A97A136A121A122A123A124A131A132A137A136GSK3A131A132A137A136A138A127A128A76A77A81A82A139A80A140A141A72A142A143A144ADA145A100A101A146A147A148A74A146A149A138A74A150A146A151A132A152A153A79A154A128,A69A155A156A157A158A159A120ADA79A160A113A161A147A90A79A138A162A163A164A108A109A165A132A106A166A167A100A101A168A86A79A169A170A171A172A83A173AA121A174A175A160A113A79A141A176A177A178TAUA179A180A161A181A182A183A114A184A185A79A186A187A188A189A190A191A104A192A80ADA193A194A79A140A195A196A197A83A149A198A131A132AA121A79A193A194A178TAUA179A180A161A181A182A183A114A158A199A200A201A202A203A204ADA79A150A194A106A205A206A207A208A209A79A210A128A211A212A83A206A207,A213A120A141A176A177A214A215A113A122AA121A79A216A217,A120A121A122A123A124A74A218A122A123A124A79A131A132A205A214A215A127A1281A219A220TAUA179A180A161A181A182A183A114,GSK3A131A132A137A205A208A209A210A1282A83A221A222,A223A224A120A225A90A130A226A124A108A109A131A132,A187A227A228A229A230A231A232A233A124A79A225A234A235A82,A100A101A236A237A79A238A239A240A93A83A69A155A69A70A112A113A120A241A162A127A128A229A230A76A77A79A131A132A137,A86A242A243A93A77A90A244A219A220A245A77A137A246,A199A222A247A248A100A101A249A94A250A251A79A114A112A82A83A252A253A81A94A135A96A97A79A254A255A106A114A112A82A156A157A158A159A53A112A81A94A135A96A97A106A215A101A244A158A100A101A92A93A79A81A0A71A72A83A217A198A1A2A156A157A233A114A112A82A229A230A53A112A241A162A217A202A79A81A94A135A96A97A106A220A101A244A158A229A230A76A77A80A241A162A217A202A79A127A128A106A199A222A162A249A114A112A82A79A194A82A91A77A181A106A222A73A81A0A71A72A106A223A250A251A75A76A77A83A217A138A226A3A4A5A79A100A101A236A6A194A82A71A72A79GSK3A131A132A137A49A7A8A175A9A10A81A94A135A96A97A83A86A198A96A97A178A3A9A10A79A218A122A123A124A131A132A137A81A94A135A96A97A79A45A11A202,A120A201A242A41A12A3A69A70A112A113A79A121A122A123A124A131A132A137A108A109A104A105A110A111,A217A195A247A248A120GSK3A178A121A122A123A124A129A100A101A236A6A131A132A71A72A79A104A105A43A13A79A14A15A114A112A82A83A239A77A112A16A79A84A85A120A17A69A70A79A114A112A82A108A109A112A113A107A122A18,A243A181A236A249A79A114A112A82A108A109GSK3A131A132A178A218A122A123A124A131A132A79A81A0A242A41A83A166A81A0A242A41A104A157A129A19A70A20A151A21A22A81A82A69A70A23A24,A41A55A81A94A135A96A97A178A69A70A79A104A157,A49A114A112A82A79A108A130A163A228A25A125A26A27A28A29A45A11A831A30A30A31A32A33A34A35A31A32A33A34A31A36A37A38A39A40A42A36A37A38A39A42A44A46A47A44A46A4411A48A50A51A52A54A56A57A58A163A59A60A61A62A63A64A65A66A56A67A68A69A70A71A72A76MDDRA77A59A73A74A75A78A79A249A80A214A52A67A68A69A70A71A56A51A52A54A72A89A81A82A74A56A51A52A54A83A84A85A86A87A88A90A251A91A102A92A93A94A52GSK3A64A65A66A56A67A68A69A70A713A87GSK3A95A96A97A98A81A99A100A232A56A94A101A103A104A57A58A79A105A106A94A101A81A99A56A51A52A54,A107A108A109A110A111A112A113A110A108A109A114,A110A165A115A92A116A117A107A118A119A232A120A121A51A52A54A56A122A123/A124A123A114A125A57A58A79A56A51A52A54A94A101A126A127A1281A72A130A52A94A131A132A1282NOONOOOORRA1331A241A134A135A136A137A138A139A136A140A14112A142A143A137A138A139A144A145A136A146A147A148A149A150A218A151A145A152A153A134A135A136A137A138A139A154A155A156A152A157A158A159A160A161A1641CRH2CROCH33CRMCH34CRPCH35CRMCL6CRPCL7CROOCH38CRPOCH39CRMNO2GSK3A159A160A161A136A151A166A167A168A169A170A171A146A147A144A145A148A149A164A218A151A145A152A153A172A140A173A174A175A176A134A135A136A137A138A139A177A178A179A136A180A181A182A183A184A185A186A136A144A145A176A187A188A189A190A191A192A193A194A195A196A197A198A199NMOL/LA200A201A202A189GSK3A194A195A196A197A198A199A203MOL/LA200A201A204A205A206A207A208A209A210A211A208A212A213A216A219A2214A202A224A225A195A196A194A226A207A227A229A230TPSAA231A2339322A202A23490A235A236A202A237A238A207A208A209A240A242A244A245A246A247A248A250A20413A208A252A253A254A255A3A191A54A194A189A10A87A0A194A1A2A202A212A57A55A4A208A252A30TWODIRECTIONALSYNTHESISA31A75A202A242A5A6A59A232A233A189A10A188A60A202A4A200A61A90A7A55A4A208A252A30A82A31A34A9A11A11A9A11A11A12A11A13A14A15ZNCL2A16A17A16A17A18A18NH2RCLOOCH3CHOH,CH3COONAHNOROCLCLOOCHCL3NOONOOOORRA192A35A20A53A21A22A23A21A24A62A252A26A201A27A28A29A64A32A33X5A36A37A38A64A32A39A40A66A39A40A41A67A144A68A42A70A73UVA43A71A44A45A46A66A43756PCSPECTRUMA165A47A45A46A66A48A49A77A50A51A102IRA43SPECTRUMONEA80A231A81A52A56A58A63A65A94A69A721HNMRA7413CNMRA76A78A79A82PARIANMERCURYVX300A83A84A85A86A88A65A7221A89A91A92A93A95A96A97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130232C3,5,129924C2,6,61541C11,51441C9,29439C8,14342C12A73237A62NA183A63A64A123A58NA32A64A65A63A58A66A62A67A62A687CA40A112A148A42A73A156A12142A44MP112114A120A73IRKBR,A159/CM1175502A160CO118253,102311A160CO165961A160CO128964A160ARN306578A160ARH,159993,150227,146816A160CC,75107A161ARH1HNMR300MHZ,CDCL3,A161PPM69167436A478H,M,H25A49,48932H,D,H7,41194H,M,H8,38086H,M,2CH3O,35962H,M,H4,24262H,M,H6,23142H,M,H6,12296H,M,H913CNMR300MHZ,CDCL3,A161PPM173103A47C7A49A44169851,169779A47C10A49A44112042154970C16,61161C11,556912OCH3,50142C9,29123C8,14342C12A73238A62NA69A63A64A123A58NA32A64A65A63A58A66A62A67A62A688CA40A112A148A42A73A156A12142A44MP118121A120A73IRKBR,A159/CM1174237A160CO121530,102238A160CO165173A160CO133321A160ARN151288,146278A160CC,84064A161ARH1HNMR300MHZ,CDCL3,A161PPM72754H,M,H1,5,68024H,M,H2,4,42914H,M,H7,41634H,M,H8,38246H,M,CH3O,23974H,S,H9,12406H,M,H913CNMR300MHZ,CDCL3,A161PPM172959A47C7A49A44169607A47C10A49A44159442A47C4A49A44135523A47C1A49A44129558C2,6,115050C3,5,61333C11,516913OCH3,51664C9,29446C8,14350C12A73239A62NA183A63A64A123A58NA32A64A65A63A58A66A62A67A62A689CA40A112A148A42A73A156A12114A44MP167169A120A73IRKBR,A159/CM1175149A160CO120406,102369A160CO166963A160CO134920A160ARN307212A160ARH,153209,148045A160CC,69956A161CC1HNMR300MHZ,CDCL3,A161PPM7270982908H,M,H1,3,4,5,43674H,S,H7,41804H,M,H8,24274H,M,H6,12725H,M,H913CNMR300MHZ,CDCL3,A161PPM171789A47C7A49A44168996A47C10A49A44149198A47C3A49A4413714A47C1A49A44135135C6,130986C5,123786C4,123614C2,61814C11,51412C9,29625C8,14321C12A733A42A75A76A77A78A7931A69GSK3A55A80A81A82A52GSK3A83A168A84A85A184A88A89A90A91A92A93A94A53A55A138A111A188A98A34A99A142A40A44A191A78A100A60A53A51A54A69A34A99A102A76A77A55A80A81A44A217A192A103A193A134A53A51A54A55A105A52A106A107A73A239A52A194A218A108A54A11033PA114A116A55ATPA44A78A79A108A54A9033PA196A118A204A44A197A119A102A76A77A55A125A53A217A127A53A51A54A69A50A80A81A200A129A73A163A130A53A51A54A131A132A204A127A80A81A121A135A136A39A45A53A51A545CA140393A141MOLL1A190A69GSK3A83A55A80A81A121A228A473381A2021481A49A147A53A51A548CA140A203A150A228399A141MOLL1A190A69GSK3A83A55A80A81A121A228A474465A2021626A49A73A91A151A241A152A135A55A53A51A54A69GSK3A83A153A154A155A157A158A162A164A165A166A16732A170A172A174A175A176A162A164A165A166A179A166A185A187A189A195A249A198A201A189A195A206A207A172A174A175A176A208BACE1A209A210A211A212A213A214A167A215A166A216A219A220A221A222A223A224A225A208FRETA209A158A226A227A229A230A176A231A232A167A233A234A235A236A237A158A238A240A174A242A243A154A216A219A244A219A245A246A247A248A250A245A246A201A251A236A237A252A253A254A255A107A201A156A0A158A1A167A233A219A244A219355NMA201A244A220A219460NMA158A221A2A3A229A230A207A216A219A208A4A135A201A49A124A216A219A208A4A135A158A199A53A197A5A176A231A232A45A53A6A237A170A7A158A162A164A200A8A167A252A224OM992A165A51A225A232A162A164A67A167A53A6A2373CA233A203A144A51427A35MOLL1A190A170A172A174A175A176A158A162A164A121A51A208589A20212