多发性骨髓瘤化疗方案

1、化疗方案骨髓瘤方案药物剂量用法时间ABVD每28天一周期阿霉素25mg/nrivdl, 15博来霭素lOme/m2ivdl, 15XX碱6mg/m2ivdh 15达卡巴嗪375mg/m2ivdh 15BACOP（*为加强方案）阿霉素25mg/m2 (*40mg/m2)或ivdl, 8每28天一周期环磷酰胺EPI 40mg/m2 (*50mg/m2)650mg/m2ivdl, 8XX新碱1.4mg/m2ivdl, 8泼尼松40-60mg/m2p°d 15-28博来霉素10mg/m22ivdl5, 22BEACOPP（*为加强方案）阿霉素25mg/m2 (*35mg/m2)ivdl每21

2、天一周期环磷酰胺650mg/m2 (*1250mg/m2)ivdl依托泊昔100mg/m2 (*200mg/m2)ivdl-3XX新碱1.4mg/m2 (max 2mg/m2)ivd8甲基节腓100mg/m2p°dl-7泼尼松40mg/ni2p°dM4博来霉素10mg/m2ivd8dex-DEAM卡莫司汀60mg/m2ivd2美法仑20mg/m2ivd3依托泊昔200mg/m2iv,Q12hd4-7阿糖胞昔lOOmg/nriv,Q12hd4-7地塞米松8mepo, tiddMOmini-DEAM卡莫司汀60mg/m2ivdl美法仑30mg/m2 (max 50mg)ivd5

3、依托泊昔75mg/m2ivd2-5阿糖胞昔100mg/m2iv,Q12hd2-5CHOP14天或21天一阿霉素50mg/m2 (或 EPI 80mg/nr)ivdl周期环磷酰胺750mg/m2ivdlXX新碱1.4nig/m2ivdl泼尼松lOOnigp°dl-5CHOP-E每21天一周期阿霉素50mg/m2(或 EPI 80mg/m2)ivdl环磷酰胺750mg/m2ivdlword 版ivdlivdl-3Podl-5)ivdlivdlivdlP°dl-5ivd 1,3,7,9,11ivdlivdlivdlP°dl-5ivdlivdl, 8P°dl-5

4、ivdl, 8ivdl, 8P°dl-14P°dl-14ivdl-5ivdlP°dl-5ivdl-3 （水 化）ivd5-10ivdliv,Q12hd2ivdl-4ivdl-4ivdl-4ivdl-4P°dl-10iv （连续dl-4XX新碱 依托泊昔 泼尼松CHOP-L-ASP每21天-周期阿霉素 环磷酰胺 XX新碱 泼尼松 左旋门冬 酰胺酶CEOP 每21天-周期环磷酰胺 依托泊昔 XX新碱 泼尼松COP每14-21天一周环磷酰胺期XX新碱 泼尼松COPP每28天-周期环磷酰胺 XX新碱 丙卡巴脐 泼尼松CVP 每21天-周期环磷酰胺XX新碱 泼尼松

5、DDP-VP-16 每21天一周期顺钳依托泊昔DHAP每14-21天一周顺钳期阿糖胞昔 地塞米松DICE每21天一周期异环磷酰 胺 顺釦依托泊昔 地塞米松EPOCH每21天一周期阿霉素1.4mg/m2100mg/nr lOOmg50mg/nr(或 EPI 80mg/m 750mg/m21.4mg/m2 (max 2mg) lOOmg6000U/500mg/m237.5mg/m22mg75mg/nr750mg/m21.4mg/m2 (max 2mg) lOOmg600-800mg1.4nig/m2 (max 2mg)lOOmg/m240mg/m2400mg/m21.4 (max 2mg) lOO

6、mg30mg/m240-50mg/m2lOOmg/nr2g/nr40mg1000mg/m225mg/nr60mg/m26-9mg/m210mg/m296h)依托泊昔XX新碱环磷酰胺泼尼松50mg/nr0.4mg/m2750mg/m260mg/m2iv (连续96h)iv (连续96h)ivPodl-4dl-4d5dl-5EPOCH每21天-周期依托泊昔60mg/m2ivdl-4顺钳25mg/m2iv (连续96h)dl-4中泼尼龙500mg/m2ivdl-4阿糖胞昔2g/nrivd5FC每28天-周期氟达拉滨25-30mg/m2ivdl-3环磷酰胺250-300mg/m2ivdl-3FCM 每

7、28天-周期氟达拉滨25mg/m2ivdl-3米托蔥醒6-8mg/m2ivdl环磷酰胺200mg/m2ivdl-3FCM 每28天-周期氟达拉滨25mg/m2ivdl-3米托蔥醍10mg/m2ivdl地塞米松20mgiv/podl-5GDP每21天-周期吉西他滨1000mg/m2ivdl, 8顺釦75mg/nrivdl地塞米松40meivdl-4GemOx吉西他滨lOOOmg/nrivdl奥沙利钳100mg/m2ivdlICE依托泊昔100mg/m2ivdl-3异环磷酰5000mg/m2iv (24h胺输注）d2卡钳按 AUC=5t max800nigivd2IVE每21天-周期表阿毒素50m

8、g/m2ivdl异环磷酰 胺3OOOmg/m2iv (22h)dl-3依托泊昔200mg/nriv (>2h)dl-3MACOP-B每12周重复一阿霉素50mg/m2ivwkl,3,5,7周期9,11环磷酰胺350mg/m2ivwk 1,3,5,7.9,11XX新碱1.4mg/m2 (max2mg)ivwk246 &10J2博来霭素10mg/m2ivwk4,8,12泼尼松75mg/dP°wkl-11 后逐渐减量wk2610MIMEMethy-500me/m2ivdlguazone 异环磷酰胺1000mg/m2ivdl-5依托泊昔lOOmg/nrivdl-3中氨蝶吟30m

9、g/nrivd3MOEP每21天一周期米托蔥醍lOmgivdl-3XX新碱1.4mg/m2 (max2mg)ivdl依托泊昔lOOmgivdl-5 (7)泼尼松60mgP°dl-5 (7)MOPP每28天-周期氮芥6mg/m2ivdl, 8XX新碱1.4mg/m2ivdl, 8丙卡巴脐lOOme/m2P°dM4泼尼松40mg/m2P°dM4SMILE每28天-周期屮氨蝶吟2g/nrivdl异环磷酰 胺1500mg/m2ivd2-4依托泊昔lOOmg/nrivd2-4地塞米松40mg/m2ivd2-4L-ASP6000U/m2ivd& 10J2J4,16 J

10、&20HD-MTX中氨蝶吟l-3giv (12h)dlHD-AraC阿糖胞昔3g/m?iv,Q12hdl-3 (6)ABCM阿霉素30mg/m2ivdl卡莫司汀30mg/m2ivdl环磷酰胺lOOmg/nrP°d22-25美法仑6mg/m2P°d22-25DCEP地塞米松40mg/dIv/podl-4环磷酰胺400mg/m2iv,持续dl-4依托泊昔40mg/nriv,持续dl-4DT-PACE顺钳10mg/m2iv,持续dl-4地塞米松40mg/div/podl-4沙利度胺400mg/dP°维持阿霉素10mg/m2Ivdl-4顺钳10mg/m2iv,持续

11、dl-4环磷酰胺400mg/m2iv,持续dl-4MP依托泊昔40mg/ni2iv,持续dl-4每4-6周一周期美法仑10mg/m2p°dl-4M2泼尼松50mg/nrp°dl-4美法仑8me/m2p°dl-4卡莫司汀20mg/m2ivdl环磷酰胺400mg/nrivdlXX新碱1.2mg/m2ivdlPEDA泼尼松40mg/m2,20mg/m2P°d1-7,8-14顺钳20mg/m2ivdl-4依托泊昔100nig/m2ivdl-4地塞米松40mg/divdl-5VAD阿糖胞昔lg/m2ivd5XX新碱0.4mg/m2ivdl-4阿霉素9mg/m2iv

12、dl-4LD地塞米松40meP°dl-4,9-12,17-20雳利度胺25mg/dP°dl-21LR地塞米松40mg/div/podl4912,l7-20雷利度胺25mg/dp°每月wks 1-3L+DVD利妥昔单 抗375me/m2ivwks2-5J3-16雳利度胺lOmg/dp°dl-21脂质体阿 霉素40mg/nrivdlXX新碱2mgivdl地塞米松40mg/dp°dl-4L+MP雷利度胺5-10mg/dp°dl-21美法仑0.18-0.25mg/kg/dp°dl-4CTD泼尼松2mg/kg/dp°dl-4

13、沙利度胺200mgp°dl-28环磷酰胺50mg/d,bidp°dl-21MPT地塞米松50mg/d,Qodp°dl-4,15-21沙利度胺lOOmg/dp°dl-28美法仑4mg/m2p°dl-7TD泼尼松40mg/m2p°dl-7沙利度胺200mg/dp°dl-28地塞米松40mg/dp°dl-4,9-12,17-20 （奇数 周期）TDD40mg/dp°dl-4 （偶数 周期）沙利度胺lOOmg/dp°dl-28脂质体阿 霭素40mg/m2ivdlTP地塞米松40mg/dP°dl

14、-4,9-12,17-20沙利度胺200mg/dP°QdVD泼尼松50meP°Qod硼替佐米1.3nig/m2ivdl,4, &11VMP地塞米松40mg/divdl-4,9-12,17-20 （奇数 周期）dl-4 （偶数 周期）硼替佐米1.0-1.3mg/nrivdl,4,8,11,22,25,29,32美法仑9mg/m2ivdl-4PDA泼尼松60mg/m2P°dl-4硼替佐米1.3mg/m2ivdl,4, &11阿霉素0,4,5,9mg/m，ivdl-4地塞米松40mg/div第1周期：dl-4,8-11,15-18 第2-4周期：dl-4VTD硼替佐米1.3mg/m2ivdl,4, &a