[研究方向一]致癌和抗癌理论的研究及天然抗癌药物的筛选

1、招聘博士后研究方向一：致癌和抗癌理论的研究及天然抗癌药物的筛选研究内容： 致癌物质在体内代谢后如何通过细胞膜、核膜，到达细胞核，引起DNA突变，而导致癌变的机理；抗癌物质在体内代谢后如何通过细胞膜、核膜，到达细胞核，与DNA作用，抑制或干扰DNA的复制、翻译和表达，最终导致癌细胞死亡。研究从天然物质中提取和分离出有效成分或有效部位的方法，并对有效成分或有效部位进行一系列的毒理和药理实验，评估其生物活性和药用价值。对一些有价值的传统中药药方进行研究和破译，分析其化学物质组成和比例，找出其有效成分或有效部位，并研究方剂中的各种有效成分的协同作用机制和治病机理，为中药现代化做一些探索。我们对博落回、

2、白屈菜、雷公藤、垂盘草等天然植物进行了大量的提取和分离研究；并分离出了血根碱、乙氧基血根碱、氧化血根碱、白屈菜碱、白屈菜红碱、乙氧基白屈菜红碱、白屈菜黄碱、白屈菜玉红碱、原阿片碱、-别隐品碱、-别隐品碱、黄连碱、小檗碱(黄连素)、沙明碱、博落回碱，雷公藤内酯醇（雷公藤甲素）、雷公藤内酯二醇（雷公藤乙素）、雷公藤内酯酮、雷公藤碱，N-甲基异石榴皮碱、二氢- N-甲基异石榴皮碱、垂盘草甙等单体。并正在对这些物质的单体或各种单体的配伍进行一系列的毒理和药理实验，评估其单体或方剂的生物活性和药用价值。目的：认识致癌物的致癌机理和抗癌物的抗癌机理，根据致癌和抗癌机理，设计或筛选低毒和高效的无致癌活性的抗

3、癌新药；同时，也希望获得治疗其它疾病的天然药物。研究方向二：环境污染控制与“三废”治理的研究（即“DDS催化剂催化下烟道气脱硫机理的研究”）研究内容：DDS催化剂是一种含铁的络合或螯合物。用含DDS催化剂和亲硫耗氧性耐热耐碱菌的碱性溶液脱硫的方法是一种全新的湿法生化脱硫技术。该脱硫技术已经大规模地用于工业原料气脱除H2S、COS、CS2、SO2、SO3等，可以将气体中的总硫降至1mg/m3以下，且副产硫磺，DDS脱硫液是全循环使用，可以减轻环境污染，也无二次污染现象，产生了较大的经济效益和社会效益；但是，该脱硫法用于烟道气脱硫的机理研究还不深，需要进一步的研究和完善。目的：建立DDS催化剂催化

4、下烟道气脱硫的“气液”吸收平衡的理论数学模型，利用该模型确定DDS脱硫液的溶液组成，可以使烟道气中的总硫降至1mg/m3以下，同时，副产液体二氧化硫，或硫磺，或硫酸盐，或浓硫酸；最终实现DDS催化剂催化下烟道气脱硫技术大规模地用于烟道气脱硫，减轻大气污染和环境污染，保护环境。现计划招收1-2名博士后研究人员，从事以上研究课题的研究。凡符合国家博士后工作条件，从事过药物化学、有机化学、生物化学、药理学和毒理学、化学工程研究工作的人员优先考虑。有兴趣者请与北京大学化学与分子工程学院应用化学系魏雄辉博士联系。魏雄辉 博士地 址：北京大学化学与分子工程学院应用化学系 邮 编：100871电 话：（01

5、0）62752857，62751529，62670693-8808传 真：（010）62751529E-mail：xhweiPostdoctor Position AnnouncedResearching field one: Mechanisms of Carcinogenesis & Anticancer, Anticancer-Agents Extracted and Isolated from Chinese Medicine or Natural Plants.The study concentrates on the process how the metabolized

6、carcinogens pass through the cellular and nuclear membrane and cause DNA mutation that can induce cancers in human beings, and on the process how anticancer agentsmetabolites of alkaloid compounds from natural plants pass through cellular and nuclear membrane and reach the cell nucleus, interact wit

7、h DNA, inhibit or interrupt DNA replication, translation, and expression and result death of cancer cells and the diminish and vanish of tumor. We are trying to develop new methods for extracting and isolating active compounds from natural plants. A series of pharmacological and toxicological experi

8、ments are going on to evaluate the biological activity of these anti-cancer compounds.Currently, we are investigating several traditional Chinese prescription medicines, analyze the chemical compositions and content in order to find valid molecular monomers or parts and their collaborating effect to

9、 modernize traditional Chinese medicine.Till today, we have extracted and purified alkaloids from from Macleaya Cordata, Chelidonium Majus L., Tripterygium Wilfordii Hook f., Sedum Sarmentosum Bunge, and obtained pure sanguinarine, ethoxysanguinarine, oxysanguinarine, chelidonine, chelerythrine, eth

10、oxychelerythrine, chelilutine, chelirubine, protopine, -allocryptopine, -allocryptopine, coptisine, berberine, corysamine, bocconine; triptolide, tripdiolide, triptonide, wilforddine; N-methylisopelletierine, dihydro-N-methylisopelletierine, sarmentosin etc. These pure natural compounds are being te

11、sted in vitro, and their cytotoxicities, anti-cancer activities. Ours goal is to get further insight into the anti-cancer mechanisms of alkaloids and other natural compounds to help the discovery of anti-cancer medicines for the cure of cancers and other diseases. Researching field two: Environment

12、Pollution Control and “Three-Wastes” Treatment (“Desulphurization of Flue Gases Catalysted by DDS Catalyst”)DDS catalyst is a kind of ferric (ferrous) coordinate or chelate. The usage of basic solution containing DDS catalyst and hyperthermophilic alkalophilic thiobacillus to remove sulphides from p

13、rocess gases is a new kind of wet bio-desulphurization methods. It has being used to remove H2S、COS、CS2 from industry process gases, and can reduce sulphide general concentration below to 1mg/m3, with sulphure as byproduction, meanwhile the DDS solution is recycled. And it has been made great benefi

14、t to society. But this process has not yet used for desulphurization of flue gases. Now, we are trying to make more study on this method so as to install this process for flue gases desulphurization.Researching mission: To establish the mathematic models of phase Equilibrium for the absorbing of SO2

15、 and SO3 from flue gases by DDS solution. Make research to determine the standard production lines for flue gases desulphurization with DDS solution, by high desulphurization efficiency to reduce SO2 and SO3 concentrations bellow to 1mg/m3, with liquid SO2 and/or S as the byproductions. These technologies for desulfurization of process gases and flue gases are still ours interesting research field in order to protect our surroundings.Want 1 to 2 postdoctors to work on the above researching fields. Applicants are pleased to