ZAP-70在B细胞非霍奇金淋巴瘤中的表达及其意义_24129

1、ZAP-70B: ZAP-7070-kD zeta-associated proteinZAP-70BB Cell Non-Hodgkins LymphomaB-NHLSP60B-NHLZAP-70CD38Spearmans260B-NHL16BZAP-7075.0%ZAP-70CD38P0.0110220.0%ZAP-7013MALTmucosa-associated lymphoid tissueMALT215.3%ZAP-705Burkitts120.0%ZAP-7010Bdiffuse large B cell lymphomaDLBCL6follicular lymphomaFLZA

2、P-70BBB-NHLZAP-70 ZAP-70BBZAP-7070 kDaTNKZAP-70TNKBZAP-70BB-cell chronic lymphocytic leukemiaB-CLLZAP-70(immunoglobulin heavy-chain variable-region geneIgVH)ZAP-70BB-NHLZAP-70B-NHLZAP-701 1.1 2000-2008B-NHL603723187950WHO(2001)1.2 HESPZAP-70NeoMarkerCD38DAKOZAP-70T1PBS1.3 ZAP-70CD383()1.4 SPSS12.0 f

3、or WindowsSpearmans2 2.1 ZAP-70B ZAP-70(2)16B1275.0%ZAP-70ZAP-70CD381CD38+B3ZAP-702.2 ZAP-70B-NHL B44B-NHL10220.0%ZAP-7013MALT2(15.3%)ZAP-705Burkitts120.0%ZAP-7010DLBCL6FL (45) 3 ZAP-70sykprotein ty-rosine kinasePTKTT cell receptorTCRPTK1BZAP-70PTKsykB(B cell receptorBCR)ZAP-70ZAP-70BBB-CLL216B1275.

4、0%ZAP-70ZAP-70BZAP-70CD38P0.01CD38+BZAP-70CD38B-CLLCD383BB-CLLZAP-70BZAP-70Schweighoffer 4ZAP-70srcBBBZAP-70BZAP-704-5ZAP-70B10220.0%ZAP-7013MALT2(15.3%)ZAP-705Burkitts120.0%ZAP-7010DLBCL6FLCarreras6ZAP-70B29Burkitts931%7BB cell lympho-blastic lymphomaB-LBL229%ZAP-70Admirand7ZAP-70B-LBLBurkittsLBLZA

5、P-70BZAP-70B4ZAP-70mantle cell lymphomaMCL8nodal-Marginal zone lymphomanodal-MZLDLBCLFLMZLhodgkin lymphomaHDZAP-70BB-CLLZAP-70BBZAP-70B-CLLZAP-70BB-CLLZAP-70B-CLLZAP-70BZAP-70B-CLLZAP-70IgVHZAP-70BZAP-70ZAP-70syk1Brdicka T, Kadlecek TA, Roose JP,et al. Intramolecularregulatory switch in ZAP-70: anal

6、ogy with receptor tyrosinekinasesJ. Mol Cell Biol,2005, 25(12):4924-4933.2Chen L, Widhopf G, Huynh L, et al. Expression of ZAP-70is associated with increased B-cell receptor signaling inchronic lymphocytic leukemiaJ. Blood,2002, 100(13):4609-4614.3Krober A, Seiler T, Benner A, et al. V(H) mutation s

7、tatus,CD38 expression level, genomic aberrations, and survival inchronic lymphocytic leukemiaJ. Blood,2002, 100(4):1410-1416.4Schweighoffer E, Vanes L, Mathiot A, et al. Unexpectedrequirement for ZAP-70 in pre-B cell development and al-lelic exclusionJ. Immunity,2003,18(4):523-533.5Nolz JC, Tschumpe

8、r RC, Pittner BT, et al. ZAP-70 is ex-pressed by a subset of normal human B-lymphocytes dis-playing an activated phenotypeJ. Leukemia,2005, 19(6):1018-1024.6Carreras J, Villamor N, Colomo L, et al. Immunohistochemi-cal analysis of ZAP-70 expression in B-cell lymphoidneoplasmsJ. J Pathol,2005,205(4):507-513.7Admirand JH, Rassidakis GZ, Abruzzo LV, et al. Immunohis-tochemical detection of ZAP-70 in 341 cases of non-Hodgkinand Hodgkin lymphomaJ. Mod Pathol,2004, 17