Sindirim Sistemi

1、GgastrincirculationHClvagus nerveFOODDistensionPeptidesGastric Phase of Gastric Secretion (initiated by gastric events)GgastrincirculationHClvagus nerveCephalic Phase of Gastric Secretion (initiated by brain)Phases of Gastric Secretion H/KPH/KPhistamine-secreting cellAcetylcholine neural input Gastr

2、in hormonal input PARIETAL cell release of histaminehistamine receptorACh receptorgastrin receptortransduction-activation eventsHClsecretionCombined neurocrine, endocrine and paracrine events in the activation of gastric HCl secretionECL cellECL cell = enterochromaffin-like cellHOW IT WORKS AT THE R

3、ECEPTOR LEVELTurning the G-cell On and Off AChAChAChGRP(Somatostatin)cell(Gastrin)cellSSGRPneurondigestedproteinH+vagusnerveCirculatingGastrinGD+-+cholinergic neurongastric mucosaGastric LumenGastric LumenTurning the G-cell On and Off AChAChAChGRP(Somatostatin)cell(Gastrin)cellSSGRPneurondigestedpro

4、teinH+vagusnerveCirculatingGastrinGD+cholinergic neurongastric mucosaGastric LumenSS = somatostatin-Intestinal Phase of Gastric Function D. Duodenal Integration & Control Duodenal Response to AcidityRegulation by Secretin+-+gallbladderliverHClHClmotility NaCl+ H2OHCO3HClNaHCO3NaHCO3Regulation by CCK (Cholecystokinin)gallbladderBileFOOD+-liver+fats & peptidesbile &a