Ginkgolide-A-BN-52020-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGinkgolide ACat. No.: HY-B0355CAS No.: 15291-75-5Synonyms: BN-52020分式: CHO分量: 408.4作靶点: GABA Receptor作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month

2、溶解性数据体外实验 DMSO : 100 mg/mL (244.86 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4486 mL 12.2429 mL 24.4858 mL5 mM 0.4897 mL 2.4486 mL 4.8972 mL10 mM 0.2449 mL 1.2243 mL 2.4486 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为

3、保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.12 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.12 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 9

4、0% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.12 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Ginkgolide A (BN-52020) 提取银杏叶，是GABA 拮抗剂。IC50 & Target GABA Receptor 1.体外研究 Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from t

5、he leaves ofthe Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders.Ginkgolide A significantly shortened the sleeping time induced by anesthetics in mice 1. Ginkgolide A (BN-52020) failed to affect apoptotic damage neither in serum-deprived nor in stauro

6、sporine-treated neurons 2.REFERENCES1. Wada, K., et al., Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics.Biol Pharm Bull, 1993. 16(2): p. 210-2.2. Ahlemeyer, B. and J. Krieglstein, Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimersdisease. Pharmacopsychiatry, 2003. 36(S 1): p. 8-14.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te