1S-3R-RSL3-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(1S,3R)-RSL3Cat. No.: HY-100218ACAS No.: 1219810-16-8分式: CHClNO分量: 440.88作靶点: Glutathione Peroxidase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (

2、226.82 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.67 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.67 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 (1S,3R)-RSL3种胱肽过氧化物酶4 (GPX4) 抑制剂，

3、在细胞试验中EC50 为10 M。户使本产品发表的科研献 Cell Death Dis. 2019 Apr 15;10(5):331. Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. FEBS Open Bio. 2018 Dec.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Christina Schott et al. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyos

4、arcoma Cells to Oxidative Stress-InducedFerroptotic Cell Death.Front Oncol. 2015, 5: 131.2. Michel Weiwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic &Medicinal Chemistry Letters 22 (2012) 1822-1826.3. Wan Seok Yang et al. Synthet

5、ic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death inOncogenic-RAS-Harboring Cancer Cells. Chem Biol, 2008 Mar, 15(3): 234-245.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955