EPZ020411-hydrochloride - Histone Methyltransferase 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEPZ020411 hydrochlorideCat. No.: HY-12970ACAS No.: 2070015-25-5分式: CHClNO分量: 479.06作靶点: Histone Methyltransferase作通路: Epigenetics储存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解

2、性数据体外实验 DMSO : 50 mg/mL (104.37 mM; Need ultrasonic)H2O : 41 mg/mL (85.58 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0874 mL 10.4371 mL 20.8742 mL5 mM 0.4175 mL 2.0874 mL 4.1748 mL10 mM 0.2087 mL 1.0437 mL 2.0874 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注

3、意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.22 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubili

4、ty: 2.5 mg/mL (5.22 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.22 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 EPZ020411盐酸盐种有效的选择性PRMT6 抑制剂, IC50为10 nM,作于 PRMT1 和PRMT8选择性10倍多。户使本产品发表的科研献 EMBO Rep. 2018 Dec;19(12). pii:

5、 e46377.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 ToolCompound.ACS Med Chem Lett. 2015 Apr 6;6(6):655-659.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5