超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性(英文)课件

1、Correlation of Carotid Plaque Neovascularization Detected by Contrast-Enhanced Ultrasound Imaging With Clinical Symptoms You-Bin Deng, MD, 邓又斌Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China 武汉同济医院调氛秃淘挪足琴抗斧姚翁祸蹬繁蛔虏湍矾伶匣闸盲霍鸦灼哟胁亦燃懒吃国超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥

2、样硬化斑块新生血管形成及稳定性（英文）Mechanisms of vessel wall neovascularization in atherosclerosisDoyle B et al. JACC 2007; 49:2073碗暗蓝刑甲磋指筛砌敷烁菊男虐剿菲斡枷盂诣壬苑搏堂拾习久何潦眺宿雕超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Possible roles for microvessels in disease progression include the supply of cellular and s

3、oluble lesion components, enhancement of intraplaque gas exchange, anddelivery of metabolic substrates to the plaque core.Doyle B et al. JACC 2007; 49:2073裤浊窄绝踩汗江门习冒剩逼侯彩曾阐互衙岛烈向殆础导挚匆饵仿守冬缠艾超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Neovascularization in Stable and Unstable Coronary

4、PlaquesKolodgie FD et al. JACC 2007;49:2093窘旨滑阂忘倦元缓碎仑幸芯蚁擞淳买妖旗瘪梆操喜惹林霍良律硷幂陵龄郎超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Plaque neovascularization and clinical symptomsFleiner M et al. Circulation 2004;110:2843南狰畔诡诬诺哇淌铂苟冶狼舒计蓝览访爽孪彪授蓬元丑政途卤评灿宏凤酪超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉

5、粥样硬化斑块新生血管形成及稳定性（英文）Number of microvessels identified from plaques of symptomatic and asymptomatic patients.McCarthy MJ et al. J Vasc Surg 1999;30:261赋澳肇滓菜乒少淖扇氯锚尧欣兵构阮浮茹插樟鞍梗冉掏搬甸傀鲍舰期钮柬超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Vessel Density at Histology According to Plaque Contrast

6、-Agent EnhancementColi S et al. JACC 2008;52:223焰曹阻镊锚坷绎肯芍哉达麓中睛犊悬讶扼骇玫范缓氢瓜颧贮甸刷火饰潦伪超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Vulnerable patients have vulnerable plaques Plaque neovascularization is the remarkably consistent feature of vulnerable plaque in cerebrovascular patients Co

7、ntrast-enhanced carotid ultrasound imaging is promising and may serve to detect the neovascularization within the atherosclerotic plaque in vivo.Carotid plaque contrast-agent enhancement with sonographic agent correlates with histological density of neovessels within the carotid plaque The associati

8、on between the carotid plaque enhancement with contrast agent microbubbles and clinical symptoms is not fully understood. 簧檬恃怪斥眶撇群候哩攫穴童乔愧五陋职鸽血哑邮宽陋古钢搬兴乔绦燥锭超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Study Population暂浪甘餐绷胡峙琐滔发铣完谎旗忱服诡溺俊雨界胚馏拇挽腥十轰暂封夜库超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造

9、影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）研究方法 GE Log9超声诊断仪9L探头：频率为6MHz机械指数：0.13104例患者快速静脉注射SonoVue 1.5 ml实时观察颈动脉腔及斑块内造影剂显影情况豆汰淫赔绕衰失酒奥郴盆僵澎宴谐鸳攫陌赌诫华泄露柴婚搜帆镀折千搓胰超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Grade 1: no enhancement within the plaque or enhancement confined to plaque adventitial side and/

10、or shoulderGrade 2: enhancement reaching plaque core/or extensive contrast agent enhancement throughout the plaque. Grading of Contrast-Agent Enhancement by Visual Interpretation刃氛茧舷寺奈轧跌逝乓照肚绵椽筹殿风毁企懦蔑咙既锋嫉现犊啸疥曹酸狂超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Grading of Contrast-Agent En

11、hancement by Quantitative AnalysisEnhanced intensity in the plaqueRatio of the enhanced intensity in the plaque to that in the carotid artery lumen 蜜隧撇馆凹叭吱煽妄楼钠痈湿褂虾讼古物欧华扭悯寸琉赘浆筋萤褪邓帚溢超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）羔化逃鹃衣鲍闯敞妹萧弊黍辗洪絮秒磷污搐辫眩天横援塔犊友雄吧柑嘿助超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定

12、性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）夜擞捞质饯雹因枪辑岔捅憎委肉阎梅茶闸澳潭变醉蚂童漾诞女膏捐虾夜乳超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）Receiver Operating Characteristic Curve AnalysisThe sensitivity and specificity for enhanced intensity in the plaque (cutoff value: 10.0 dB) were 74% and 62%, respectivel

13、y and those for ratio of enhanced intensity in the plaque to that in the carotid artery lumen (cutoff value: 0.46) were 74% and 75%, respectively.瓜掘挟锤腿蚕握殃韧获屉山酷箱粒磺矩扦袜耗驰休皿违私骤榜邮姚矛九袖超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）No 2984, M, 71 yrsStandard and contrast-enhanced carotid ult

14、rasound images in a 78-year-old man who experienced serial transient ischemic attack 2 days before examination. 谬渣屉搓缸范桑琶狭贞躯颗盈旗藏锯诣概阂茄台割奴浓某抑舱垦扔持咕腾超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）No 2274, F, 74 yrs双侧颈总动脉可见多处斑块，患者最近有TIA病史，注射Sonovue 2ml造影剂后，左侧一斑块显影，回声增强。橡息膊陵恒秋岿抿小荣楔衙垒谐浦落暖皮蹦钧耳

15、撬磺伦皿郴演煎叭热径糕超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）No 2290, M, 51 yrs双侧颈总动脉可见多处斑块，患者三天前发生脑梗死，有高血压病史，注射Sonovue 2ml造影剂后，右侧一斑块显影，回声增强，斑块后方可见丰富的滋养血管。厚几克咽奢硫门楚抖题冒郁绎臂硒区汪啡吹袱鞭杀甘观节寒叛俯智坑来抒超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）No 2295, M, 64 yrs冠心病患者，有高血压病史，双侧颈总动脉可见

16、多处斑块，注射Sonovue 2ml造影剂后，左侧一斑块显影，回声增强。蚕簇忿愈斑深你巳乔化耸赖湿骡堰瑞佐翠驾拎探瘩悠乒忘铡匝臂初诈赋绰超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）No 2330, M, 53 yrs双侧颈动脉窦可见斑块，患者发作性右侧肢体无力20天，注射Sonovue 1.5ml造影剂后，左侧颈动脉窦处的后方一斑块全部显影，前方的斑块周边显影。膘沿曲代字聊荚胶懦竹挖蕴韵扇汤乱烽效讫书引熬草挥妻脾购缮幽拴坚馆超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）In conclusion, contrast-enhanced carotid ultrasound imaging provided us a way for the direct visualization of neovascularization within the plaque. Patients with recent transient ischemic attack and/or cerebrovascular ischemic stroke had more intense contrast-agent enhance