Efinaconazole-KP-103-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEfinaconazoleCat. No.: HY-15660CAS No.: 164650-44-6Synonyms: KP-103分式: CHFNO分量: 348.39作靶点: Fungal作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (287.03 mM)* me

2、ans soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.8703 mL 14.3517 mL 28.7035 mL5 mM 0.5741 mL 2.8703 mL 5.7407 mL10 mM 0.2870 mL 1.4352 mL 2.8703 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，

3、建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.18 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.18 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.Me

4、dChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.18 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Efinaconazole(KP-103)是新型三唑抗真菌化合物，对T. mentagrophytes SM-110的MIC值为0.0039ug/ml。户使本产品发表的科研献 Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.00442-19.See more customer validations on HYPERLIN

5、K / www.MedChemEREFERENCES1. Tatsumi Y, et al. Mechanism of action of efinaconazole, a novel triazole antifungal agent. Antimicrob Agents Chemother. 2013May;57(5):2405-9.2. Jo Siu WJ, et al. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents again

6、st a variety ofpathogenic fungi associated with onychomycosis. Antimicrob Agents Chemother. 2013 Apr;57(4):1610-6.3. Tatsum Y, et al. KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigitaltinea pedis and tinea corporis in guinea pigs. Microbiol Immunol. 2002;46(7):425-32.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: