Procyclidine-hydrochloride-racemic-Procyclidine-hydrochlorid-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEProcyclidine hydrochlorideCat. No.: HY-B1487CAS No.: 1508-76-5Synonyms: ()-Procyclidine hydrochlorid分式: CHClNO分量: 323.9作靶点: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solve

2、nt -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 10.66 mg/mL (32.91 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0874 mL 15.4369 mL 30.8737 mL5 mM 0.6175 mL 3.0874 mL 6.1747 mL10 mM 0.3087 mL 1.5437 mL 3.0874 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICA

3、L ACTIVITY物活性 Procyclidine hydrochloride种有效的抗胆碱能试剂，也具有NMDA拮抗剂的特性。IC50 & Target NMDA Receptor 1体内研究Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also knownto have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of the

4、ir anti-1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEcholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in adose dependent manner; when a marginally effective dose of the agent is combined with an ineffective doseof an alpha(2) adrenergic agoni

5、st (Clonidine or Guanabenz), the combination therapy provides effective andlong-lasting relief from neuropathic pain 1.PROTOCOLAnimal Rats 1Administration 1 Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes atransient increase in locomotor activity

6、(mainly non-ambulatory fine movements) in adult rats. Locomotoractivity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg)altered the activity levels compared

7、 to the same doses of Procyclidine administered alone. A one-wayANOVA and subsequent comparisons are also conducted to establish whether the activity levels for eachtreatment group are different from saline controls.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats.Neuropharmacology. 2003 May;44(6):739-48.McePdfHeightCaution: Product has not been fully validated for medical applications.For