Nicotinamide-riboside-chloride - Sirtuin Activator - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENicotinamide riboside chlorideCat. No.: HY-123033ACAS No.: 23111-00-4分式: CHClNO分量: 290.7作靶点: Sirtuin作通路: Cell Cycle/DNA Damage; Epigenetics储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromligh

2、t)溶解性数据体外实验 H2O : 250 mg/mL (859.99 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.4400 mL 17.1999 mL 34.3997 mL5 mM 0.6880 mL 3.4400 mL 6.8799 mL10 mM 0.3440 mL 1.7200 mL 3.4400 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Nicotinamide riboside chlo

3、ride是烟酰胺核苷 (Nicotinamide riboside) 氯化物的晶体形式，烟酰胺核苷是烟酰胺腺嘌呤核苷酸 (nicotinamide adenine dinucleotide, NAD +) 前体维素。Nicotinamide ribosidechloride 增加NAD + 平并激活 SIRT1 和 SIRT3，最终增强氧化代谢并防脂 饮诱导的代谢异常。Nicotinamide riboside chloride 于膳补充剂。IC50 & Target SIRT1 SIRT3体外研究Nicotinamide riboside chloride (0.5 nM; 24 hours

4、) reduces the acetylation status of Ndufa9 and SOD2 1.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEWestern Blot Analysis 1Cell Line: HEK293T cellsConcentration: 0.5 nMIncubation Time: 24 hoursResult: Reduced the acetylation status of Ndufa9 and SOD2.体内研究 Chronic Nicotinamide riboside chloride (p

5、.o.; 400 mg/kg/day; for 16 weeks) supplementation increasesplasma and intracellular NAD + content in a tissue-specific manner 1.Animal Model: 10-week-old C57Bl/6J mice 1Dosage: 400 mg/kgAdministration: p.o.; daily; for 16 weeksResult: Increased plasma and intracellular NAD + content in a tissue-spec

6、ific manner.REFERENCES1. Cant C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-inducedobesity. Cell Metab. 2012 Jun 6;15(6):838-47.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820